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Carbon cloth/zinc oxide/nano-gold modified electrode for simultaneous detection of erythromycin and hemoglobin

A technology for modifying electrodes and hemoglobin, which is applied in the direction of measuring devices, electrochemical variables of materials, and material analysis through electromagnetic means. It can solve the problems of no carbon cloth/zinc oxide/nano-gold modified electrodes, etc., and achieve fast detection speed and sensitivity. high effect

Active Publication Date: 2022-05-10
LIAONING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are electrochemical sensors for the detection of erythromycin and hemoglobin, they can only detect erythromycin or hemoglobin alone, and there is no carbon cloth / zinc oxide / nano-gold modified electrode that can detect erythromycin and hemoglobin at the same time related reports

Method used

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  • Carbon cloth/zinc oxide/nano-gold modified electrode for simultaneous detection of erythromycin and hemoglobin
  • Carbon cloth/zinc oxide/nano-gold modified electrode for simultaneous detection of erythromycin and hemoglobin
  • Carbon cloth/zinc oxide/nano-gold modified electrode for simultaneous detection of erythromycin and hemoglobin

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Effect test

preparation example Construction

[0023] figure 1 In the preparation process of Example 1 of the present invention, different modified electrodes contained 0.1 mol / L KCl+5 mmol / L [Fe(CN) 6 ] 3- / 4- Cyclic voltammogram (A) and EIS curve (B) in electrolyte solution (0.1 mol / L pH 7.0 PBS).

[0024] figure 1 In A, curve 1 is the CV result of the carbon cloth electrode, which shows a pair of reversible [Fe(CN) 6 ] 3- / 4- Probe ion redox peak; curve 2 is the CV result of the CC / ZnO modified electrode obtained in step b. The peak current of curve 2 is lower than that of curve 1, which indicates that ZnO nano-puffs were successfully hydrothermally synthesized on the surface of carbon cloth, and the electron transfer rate becomes smaller; curve 3 is the CV result of electrodepositing nano-gold particles on the surface of CC / ZnO modified electrode to form CC / ZnO / Au modified electrode, the peak current value of this electrode is much larger than that of curve 1 and curve 2, and the electron transfer The rate increa...

Embodiment 2

[0034] A carbon cloth / zinc oxide / nano-gold modified electrode that can be used for simultaneous detection of erythromycin and hemoglobin of the present invention is prepared according to the following steps:

[0035] a. The cut carbon cloth (1 cm×2 cm) was ultrasonically cleaned with acetone, ultrapure water, and anhydrous ethanol for 10 minutes in turn, and then the cleaned carbon cloth was placed in an electric heating blast drying oven, and dried at 60 °C. dry;

[0036] b. After soaking the carbon cloth in solution A for 30 min, dry it at 95 °C for 30 min in an electric heating blast drying oven, then put the carbon cloth in solution A and soak it for 30 min, then dry it in an electric heating blast drying oven Dry at 95 °C for 30 min, that is, repeat soaking and drying twice; then move the carbon cloth into a PTFE-lined reaction kettle containing solution B, and heat it at 95 °C for 7 h, then take out the reaction kettle and place it at room temperature Cooled overnight; ...

Embodiment 3

[0041] A carbon cloth / zinc oxide / nano-gold modified electrode that can be used for simultaneous detection of erythromycin and hemoglobin of the present invention is prepared according to the following steps:

[0042] a. The cut carbon cloth (1 cm×2 cm) was ultrasonically cleaned with acetone, ultrapure water, and anhydrous ethanol for 10 minutes in turn, and then the cleaned carbon cloth was placed in an electric heating blast drying oven, and dried at 60 °C. dry;

[0043] b. After soaking the carbon cloth in solution A for 30 min, dry it at 95 °C for 30 min in an electric heating blast drying oven, then put the carbon cloth in solution A and soak it for 30 min, then dry it in an electric heating blast drying oven Dry at 95 °C for 30 min, that is, repeat soaking and drying twice; then move the carbon cloth into a PTFE-lined reaction kettle containing solution B, and heat it at 95 °C for 7 h, then take out the reaction kettle and place it at room temperature Cooled overnight; ...

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Abstract

The invention discloses a carbon cloth / zinc oxide / nano-gold modified electrode which can be used for simultaneous detection of erythromycin and hemoglobin. The following steps are followed in sequence: first, zinc oxide nano pompons are grown on a carbon cloth flexible substrate by a hydrothermal method, Then, the nano-gold is electrodeposited on the surface of the zinc oxide nano-pompons by an electrodeposition method. The present invention can be applied to the simultaneous detection of erythromycin and hemoglobin, and the detection ranges of erythromycin and hemoglobin are respectively 1.0×10 ‑6 ~1.0×10 ‑1 mg / L and 1.0×10 ‑7 ~1.0×10 ‑1 mg / L, the detection limit was 3.38×10 ‑7 mg / L ( S / N =3) and 2.07×10 ‑8 mg / L ( S / N =3), which has the advantages of fast detection speed and high sensitivity.

Description

technical field [0001] The invention discloses a flexible electrochemical sensor based on carbon cloth, especially a carbon cloth / zinc oxide / nano-gold modified electrode which can detect erythromycin and hemoglobin at the same time. Background technique [0002] Too many antibiotics can lead to drug resistance, superinfection, neurological damage, and even drug hypersensitivity syndrome. Drug hypersensitivity syndrome, also known as eosinophilia and systemic drug reactions, is associated with viral reactions, and the common clinical manifestations are extensive mucosal rash, acute fever, lymphadenopathy, hepatitis, and hematological abnormalities With eosinophilia, it may be accompanied by changes in the function of other organs. At the same time, according to clinical analysis, drug hypersensitivity syndrome will be manifested as excessive antibiotics accompanied by reduction of hemoglobin and liver transaminases. Therefore, simultaneous detection of hemoglobin and antibio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30G01N27/327G01N27/48
CPCG01N27/308G01N27/3275G01N27/3277G01N27/48
Inventor 孙越王伟王宇萍孙宇张馨宁孟沛然
Owner LIAONING NORMAL UNIVERSITY
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