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Method and device for predicting the effect of vitrification and recovery of human mature oocytes

A technology of vitrification and prediction method, applied in the direction of medical automatic diagnosis, treatment, health care informatics, etc., can solve problems such as failure to form embryos, physical and mental harm to patients, treatment costs and time waste, and avoid time and medical resources. waste, reduce surgical risk, and address poor reproducibility

Active Publication Date: 2022-05-13
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The characteristics of oocytes themselves determine that they are extremely vulnerable to freezing damage, and may not be able to form embryos after thawing, and the oocyte retrieval operation itself has risks such as bleeding and infection, which will cause physical and mental harm to patients; on the other hand, if you give up Egg retrieval, the cost and time wasted in the process of early ovulation induction, and the super-physiological dose of estrogen in the body lead to a significant increase in the risk of ovarian hyperstimulation syndrome

Method used

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  • Method and device for predicting the effect of vitrification and recovery of human mature oocytes
  • Method and device for predicting the effect of vitrification and recovery of human mature oocytes
  • Method and device for predicting the effect of vitrification and recovery of human mature oocytes

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Effect test

Embodiment 1

[0048] A method for predicting the vitrification recovery effect of human mature oocytes, comprising the following steps:

[0049] S10. Obtain the basic information of the woman, the number of large and medium follicles, the test results of sex hormones and infertility-related diseases, and the results of the semen examination of the man, and determine the method of sperm collection according to the semen test results of the man. Sperm collection methods include ejaculation, percutaneous epididymis / testicular aspiration, and percutaneous epididymis / testicular aspiration under a microscope.

[0050] The information obtained is obtained from the clinical history data and laboratory test results of both men and women before egg retrieval. The basic information of the woman includes the age of the woman, the duration of infertility, the test results of sex hormones include follicle stimulating hormone and estradiol, and the results of infertility-related diseases include whether s...

Embodiment 2

[0079] A device for predicting the vitrification recovery effect of human mature oocytes, comprising: a memory, a processor, and a computer program stored on the memory and operable on the processor, and the processor implements the computer program described in Embodiment 1 when executing the computer program the forecasting method described above.

[0080] Such as figure 1 As shown, the computer program stored on the memory includes the following functional modules:

[0081] A data collection module 10 , a prediction probability calculation module 20 of no embryo transfer, a cumulative live birth prediction probability calculation module 30 and a resuscitation effect prediction module 40 .

[0082] The data collection module 10 is used to obtain the basic information of the woman, the number of large and medium follicles on the day of application of follicle-stimulating drugs, the test results of sex hormones and the results of infertility-related diseases, and the results ...

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Abstract

This application relates to a method and device for predicting the effect of vitrification and recovery of human mature oocytes. The prediction method includes obtaining the basic information of the woman, the number of large and medium follicles in the application of follicle-stimulating drugs, test results of sex hormones, and infertility-related diseases. The results, as well as the man's semen test results; calculate the predicted probability P of no embryo transfer for the proposed egg cell cryopreservation operation 1 and the cumulative predicted probability of live birth P 2 ;according to P 1 and P 2 The numerical value predicts recovery effect. The forecasting device includes a memory, a processor, and a computer program stored in the memory and operable on the processor. The above-mentioned forecasting method is realized when the processor executes the computer program. This application estimates the recovery effect of the planned egg cell cryopreservation operation through the clinical history data and laboratory test results of the couple before egg retrieval, helps patients make reasonable decisions, minimizes the risk of unnecessary surgical operations and avoids Waste of time and medical resources.

Description

technical field [0001] The invention relates to the technical field of human assisted reproduction, more specifically, it relates to a method and a device for predicting the vitrification recovery effect of human mature oocytes. Background technique [0002] Assisted reproductive technology refers to the use of medical assistance to make infertile couples pregnant. Delayed childbearing age, environmental pollution, increased work pressure and other reasons make more and more couples need the help of assisted reproductive technology, and oocyte freezing is one of the important assisted reproductive technologies. [0003] During the IVF-ET treatment, if the man is unable to come to the hospital to collect sperm due to sudden illness or accident, masturbation or surgical sperm retrieval failure, or other unexpected sperm retrieval failures, or does not obtain enough sperm for assisted fertility treatment on the day of egg retrieval Emergency oocyte freezing for sperm, etc. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H50/30G16H20/00G16H50/20
CPCG16H50/30G16H20/00G16H50/20
Inventor 李蓉王洋牛子儒严杰郑晓英刘平乔杰
Owner PEKING UNIV THIRD HOSPITAL
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