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Biomarker for predicting prognosis of kidney cancer patient

A biomarker and prognosis technology, applied in the field of disease diagnosis, can solve problems such as non-response to treatment and occurrence of drug resistance

Pending Publication Date: 2021-09-24
BEIJING MEDINTELL BIOMED CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although immunotherapy has made great progress in the treatment of kidney cancer, not all patients can benefit from it. Some patients do not respond to immune checkpoint inhibitor treatment, and a small number of patients develop resistance shortly after drug application. Drugs, and immune-related toxicity (Nowicki TS, Hu-Lieskovan S, Ribas A. Mechanisms of Resistance to PD-1 and PD-L1 Blockade[J]. Cancer J, 2018,24(1):47-53 .)

Method used

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  • Biomarker for predicting prognosis of kidney cancer patient
  • Biomarker for predicting prognosis of kidney cancer patient
  • Biomarker for predicting prognosis of kidney cancer patient

Examples

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Embodiment Construction

[0051] The present invention provides kits part, detection of genetic characteristics and features of such genes / biomarker for RCC to perform the method of sample analysis, in one aspect, the present invention provides a gene signature associated with a renal survival the genetic characteristics can classify the individual risk of a poor prognosis, help guide doctors choose treatment strategies.

[0052] "And / or" it should be seen in the case of the two means with or without each of the other specific features or components of a given use disclosed herein. Example, "A and / or B" will be considered (i) A, (ii) B, and (iii) A and B of each of the specific disclosure, as each individually listed herein Same.

[0053] As used herein, the term "biomarker", "marker" and "gene signature" are interchangeable, and refer to the subject taken from a control subject, for example, with a poor prognosis of renal cell carcinoma Compare samples compared, the difference from the sample molecu...

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Abstract

The invention discloses a biomarker for predicting prognosis of a kidney cancer patient. The biomarker comprises immune related genes PLAUR, PLTP, RNASE2 and RORA, and prediction of the lifetime of the kidney cancer patient can be realized by detecting the expression level of the biomarker.

Description

Technical field [0001] The present invention relates to the field of disease diagnosis, and more particularly, the present invention relates to a biomarker that predicts prognosis of nephrogy patients. Background technique [0002] Renal Cell Carcinoma, RCC is one of the most common malignant tumors in the urinary system, divided into a variety of subtypes according to histological score, kidney cancer, where Clear Cell Renal Cell Carcinoma, CCRCC is kidney The main subtype of cancer, accounting for about 75-80% of renal cancer (Pavlovich CP, Schmidt LS, Phillipsjl.The Genetic Basis of Renal Cell Carcinoma [J] .urol Clin North AM, 2003, 30 (3): 437-54 , VII.), other types include papillary cancer, free color cell carcinoma, Bellini tube (aggregate tube) carcinoma, etc. Patients with kidney transparent cell carcinoma have the highest mortality and metastasis rate. In 2018, about 400,000 kidney transparent cell carcinoma has a new case, and there are 175,000 deaths (Lindenberg L, M...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574G01N33/68G01N33/573G16H50/20G16H50/70G16B40/10
CPCC12Q1/6886G01N33/57438G01N33/57484G01N33/68G01N33/573G16H50/20G16H50/70G16B40/10C12Q2600/118C12Q2600/158G01N2333/70596G01N2333/47G01N2333/922
Inventor 杨承刚王丹刘乐凯
Owner BEIJING MEDINTELL BIOMED CO LTD
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