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Application of Semaphorin7A monoclonal antibody in preparation of medicine for treating thrombus and cerebrovascular diseases

A cerebrovascular disease, monoclonal antibody technology, applied in cardiovascular system diseases, blood diseases, antibodies, etc., can solve problems such as limiting wide application, and achieve the effect of inhibition size, important clinical application prospects and promotion value

Pending Publication Date: 2021-10-01
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antiplatelet and anticoagulant drugs currently used clinically act on different pathways of platelet activation and various stages of thrombus formation, but they also bring a certain risk of bleeding, which limits their wide application

Method used

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  • Application of Semaphorin7A monoclonal antibody in preparation of medicine for treating thrombus and cerebrovascular diseases
  • Application of Semaphorin7A monoclonal antibody in preparation of medicine for treating thrombus and cerebrovascular diseases
  • Application of Semaphorin7A monoclonal antibody in preparation of medicine for treating thrombus and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Effect of Sema7A Knockout on Pathological Arterial Thrombosis

[0032] After Sema7a+ / + and Sema7a- / - mice were anesthetized, the branches of the carotid artery were separated and exposed, and the branches of the internal carotid artery, external carotid artery and occipital artery were ligated with 10-0 surgical thread to keep the branches of the superior thyroid artery open. The blood flow of the common carotid artery was detected by ultrasound in small animals. The blood flow velocity was reduced to 1 / 3-1 / 4 of that before the operation, and the reverse flow appeared, which was the criterion for the success of the operation. Immediately after PCL surgery, 7.5% FeCl3 injury was performed for 2 minutes (filter paper disc size 1 mm×2 mm). The filter paper is spread on the carotid artery, the damage area is large, and the clogging thrombus will quickly form in the blood vessel. This process uses small animal ultrasound to monitor blood flow changes in real time,...

Embodiment 2

[0034] Example 2: Intervention of Sema7A blocking antibody on pathological arterial thrombosis

[0035]After the wild-type mice were anesthetized, the branches of the carotid artery were separated and exposed, and the three branches of the internal carotid artery, external carotid artery and occipital artery were ligated with 10-0 surgical thread to keep the branches of the superior thyroid artery unobstructed. Sema7a blocking antibody or its control IgG antibody was injected into the jugular vein, and the blood flow of the common carotid artery was detected by ultrasound in small animals. The blood flow velocity was reduced to 1 / 3-1 / 4 of that before the operation, and reverse flow occurred, indicating that the operation was successful standard. Immediately after PCL surgery, 7.5% FeCl3 injury was performed for 2 minutes (filter paper disc size 1 mm×2 mm). The filter paper is spread on the carotid artery, the damage area is large, and the clogging thrombus will quickly form i...

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Abstract

The invention discloses application of a Semaphorin7A monoclonal antibody in preparation of medicines for treating thrombus and cerebrovascular diseases, and belongs to the field of preparation of medicines for treating thrombus and cerebrovascular diseases. According to the medicine taking the Semaphorin7A blocking antibody as the main active component, the treatment of the Semaphorin7A blocking antibody is given to a mouse in the pathological artery red thrombus forming process, and the size of thrombus can be effectively inhibited; and the application has important clinical application prospect and popularization value in research, development and production of medicines for preventing and treating cerebrovascular diseases related to thrombosis diseases.

Description

technical field [0001] The invention belongs to the field of medicine preparation for thrombosis and cerebrovascular disease, in particular to the application of Semaphorin7A monoclonal antibody in the preparation of medicine for treating thrombosis and cerebrovascular disease. Background technique [0002] Thrombosis is the abnormal coagulation of blood components in local blood vessels of the human body, which can occur in arteries or veins. Arterial thrombosis is the main cause of more than 90% of myocardial infarctions and 80% of strokes. Arterial embolic cardiovascular and cerebrovascular diseases have always been the leading cause of death in developed countries; arterial thrombosis is usually related to plaque rupture, and plaque rupture will Triggers platelet activation to form aggregates of platelets and fibrin, often containing red and white blood cells, within vessels or cardiac chambers adjacent to the endothelium or endocardium. Clinical Pathology Arterial thro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P9/10A61P7/02
CPCC07K16/2803A61P9/10A61P7/02A61K2039/505
Inventor 朱力任丽洁卢穹宇唐朝君
Owner SUZHOU UNIV
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