Determination method of amygdalin in composition capable of resolving dampness and vanquishing toxin and application of determination method

A technique for the determination of amygdalin and its method, which is applied to measuring devices, instruments, scientific instruments, etc., can solve the problems of inability to separate the peak and baseline of L-amygdalin, and achieve the effect of good specificity and good stability

Pending Publication Date: 2021-10-08
GUANGDONG YIFANG PHARMA
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Problems solved by technology

Another example is acetonitrile-potassium dihydrogen phosphate (0.02mol/L, containing 0.1% phosphoric acid and 0.1% triethylamine) (8

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  • Determination method of amygdalin in composition capable of resolving dampness and vanquishing toxin and application of determination method
  • Determination method of amygdalin in composition capable of resolving dampness and vanquishing toxin and application of determination method
  • Determination method of amygdalin in composition capable of resolving dampness and vanquishing toxin and application of determination method

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[0043] In order to make the objects, technical solutions and advantages of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0044] In the present invention, the wet-dampexic composition comprises the following weight component:

[0045] 3-60 equals, 4.5-90 speculated almonds, 7.5-150 raw gypsum, 1.5-30 licorice, 5-100 patchouli, 5-100 bran, bran at 3,500,500, fried 5-100 grass fruit kernels, 4.5-90 parts of the 15th, 7.5-150 pieces of 苓, 2.5-50 large yellow, 5-100 juveniles, 5-100 parts of the scorpion, 4-100 parts of red peony, accessories Method.

[0046]Among them, ephedrine, patchouli, gypsum is a monarch, ephedra, patchouli, Xin, bitter, warm and scent, measuring asthma, wet and medium; gypsum, Xin, Gan, Cold, Qing dynasty The heat and the three medicine are complementary, and the three drugs complement, to make a dispersion, aromatism and humidity. Fried bitter almon...

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Abstract

The invention discloses a method for determining amygdalin in a composition capable of resolving dampness and vanquishing toxins. The method comprises the following steps: by taking D-amygdalin as a reference substance, acetonitrile as a mobile phase A and phosphoric acid as a mobile phase B, eluting according to a preset elution procedure, so that a D-amygdalin peak and an L-amygdalin peak are separated, and the D-amygdalin peak and the L-amygdalin peak are both separated from a base line. The invention further discloses application of the method for determining the amygdalin in the composition capable of resolving dampness and vanquishing toxins in preparation of a composition capable of resolving dampness and vanquishing toxins. The determination method disclosed by the invention is good in specificity, good in stability, accurate and reliable. According to the method, the content of the D-amygdalin in the finished product medicine of the dampness-resolving toxin-vanquishing composition can be accurately determined, so that a good data basis is provided for quality control, formula adjustment, preparation process selection and process parameter control of the dampness-resolving toxin-vanquishing composition.

Description

technical field [0001] The invention relates to the technical field of quality detection of traditional Chinese medicines, in particular to a method for determining amygdalin in a Huashibaidu composition and an application thereof. Background technique [0002] The pneumonia epidemic caused by the 2019 novel coronavirus (COVID-19) infection has now become a pandemic worldwide. However, in the preparation process, how to combine process scale-up research and sample preparation for clinical trials, refine process parameters, strengthen quality research, determine the material basis of active ingredients, and further ensure the curative effect has become an urgent technical problem to be solved. [0003] On the other hand, for bitter almonds, its main component is amygdalin, which has the pharmacological effects of relieving cough and relieving asthma. However, studies on active ingredients in almonds have shown that amygdalin has L- and D-isomers. Among them, D-amygdalin and...

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/86
CPCG01N30/02G01N30/06G01N30/8679G01N2030/065Y02A50/30
Inventor 魏梅钟春琳童培珍孙冬梅李国卫吴文平陈向东谭梓君胡绮萍邱韵静程学仁
Owner GUANGDONG YIFANG PHARMA
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