Method for improving semen quality by regulating DPEP3

A semen and quality technology, applied in medical data mining, laboratory analysis data, instruments, etc., can solve problems such as high cost, low risk, and low cost, and achieve dipeptide content reduction, semen quality improvement, and risk reduction and cost effects

Pending Publication Date: 2021-10-19
广东省计划生育科学技术研究所
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to provide a method of regulating DPEP3 to improve the quality of semen, which has the advantages of lo

Method used

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  • Method for improving semen quality by regulating DPEP3

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Embodiment 1

[0031] A method for regulating DPEP3 to improve semen quality, comprising the following steps: Step a: select the semen of normal people, the semen of patients with varicocele and the semen after microsurgical varicocele operation to set up three groups of controlled experiments, the spermatic cord The semen of patients with varicocele is the experimental group, and the semen of normal people and the semen after microsurgical varicocele operation are the control group; The semen after the microsurgical varicocele operation is regularly and quantitatively added to PCR. After adding, the three groups of experimental products are placed in the same culture environment by the user; The metabolites of semen, semen of patients with varicocele and microsurgical varicocele surgery are collected, and the metabolites are analyzed by the experimenter; step d: the data is preprocessed by the experimenter, and The data is classified and counted; step e: the DPEP3 value expressed by the exp...

Embodiment 2

[0033] In embodiment 1, add following steps again:

[0034] Optional data analysis in step f includes hierarchical clustering analysis of differential metabolites, radar map analysis of differential metabolites, correlation analysis of differential metabolites, KEGG annotation of differential metabolites, metabolic pathway analysis of differential metabolites and differential metabolism Regulatory Network Analysis of Plants.

[0035] A method for regulating DPEP3 to improve semen quality, comprising the following steps: Step a: select the semen of normal people, the semen of patients with varicocele and the semen after microsurgical varicocele operation to set up three groups of controlled experiments, the spermatic cord The semen of patients with varicocele is the experimental group, and the semen of normal people and the semen after microsurgical varicocele operation are the control group; The semen after the microsurgical varicocele operation is regularly and quantitativel...

Embodiment 3

[0037] In embodiment 1, add following steps again:

[0038] Step d performs quantitative statistics on the data through screening, noise removal, normalization and standardization.

[0039]A method for regulating DPEP3 to improve semen quality, comprising the following steps: Step a: select the semen of normal people, the semen of patients with varicocele and the semen after microsurgical varicocele operation to set up three groups of controlled experiments, the spermatic cord The semen of patients with varicocele is the experimental group, and the semen of normal people and the semen after microsurgical varicocele operation are the control group; The semen after the microsurgical varicocele operation is regularly and quantitatively added to PCR. After adding, the three groups of experimental products are placed in the same culture environment by the user; The metabolites of semen, semen of patients with varicocele and microsurgical varicocele surgery are collected, and the m...

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Abstract

The invention discloses a method for improving semen quality by regulating DPEP3, and the method comprises the following steps: a, selecting semen of a normal person, semen of a varicocele patient and semen after a microsurgery varicocele operation to establish three groups of control experiments, taking the semen of the varicocele patient as an experimental group, and taking the semen of the normal person and the semen after the microsurgery varicocele operation as a control group; b, adding PCR into the semen of the normal person, the semen of the varicocele patient and the semen after the microsurgery varicocele operation regularly and quantitatively through an experimenter. By adopting the method designed by the invention, the content of dipeptide in the sperm metabolite can be obviously reduced, the sperm quality can be improved, the method can replace an operation to treat varicocele or improve the sperm quality, the risk and the cost of treating the varicocele or improving the sperm quality are reduced, and the current market demand is met.

Description

technical field [0001] The invention relates to the technical field of infertility, in particular to a method for regulating DPEP3 to improve semen quality. Background technique [0002] There are significant differences between the semen metabolomics of normal people and those of patients with varicocele. Among them, the increase of dipeptide metabolites and the decrease of DPEP3 activity or expression are the main reasons for the increase of dipeptide metabolites. Standard After surgical treatment of varicocele under the microscope, the quality of semen improved, and the content of dipeptide in semen metabolites decreased significantly. Further research found that it was related to the increase in the activity or expression of DPEP3 after surgery. Semen quality is not only risky but also costly, which cannot meet the needs of today's market. Due to the above problems, a method of regulating DPEP3 to improve semen quality has been introduced. Contents of the invention ...

Claims

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Application Information

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IPC IPC(8): G16B40/00G16H50/70G16H10/40
CPCG16B40/00G16H50/70G16H10/40
Inventor 张欣宗唐运革刘武江邓存灿
Owner 广东省计划生育科学技术研究所
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