Method for nanocrystallization of small-molecule sheep placenta extract

Abstract

The invention relates to a method for nanocrystallization of small-molecule sheep placenta extract. The method comprises the step (1) of preparation of a solution A and a solution B, with a preparation method of the solution A comprising diluting a small-molecule sheep placenta extract stock solution with deionized water, adding a solution containing Ca<2+> with a concentration of 1 M to prepare a Ca<2+> solution with a concentration of 0.02-0.1 M, and standing at room temperature for 10-30 minutes to obtain the solution A, a preparation method of the solution B comprising the mixing a solution containing CO<3>< 2-> with a concentration of 0.02-0.1 M and a solution containing HPO<4><2-> with a concentration of 0.02-0.1 M, and uniformly shaking to obtain the solution B; and a step (2) of mixing the solution A and the solution B to obtain a small-molecule sheep placenta extract nano composite material with nanocrystallized micromolecular sheep placenta extract. The method is advanced and scientific, the prepared nano particles are smaller than 50 nm, good in dispersity and free of peculiar smell, the biological stability of the small-molecule sheep placenta is improved, the skin penetrating efficiency and biological activity of the small-molecule sheep placenta extract are improved, and the small-molecule sheep placenta extract nano material has no obvious stimulation effect on animal eyes and has good safety.

Description

technical field [0001] The invention relates to a method for nano-molecule sheep placenta, which belongs to the fields of biotechnology and cosmetic product preparation. Background technique [0002] Nanomaterials have quantum size benefits, interface effects, and macroscopic quantum tunneling effects, etc., and exhibit many special properties in biology, such as good permeability, large solubility, and adsorption. Nanomedicine can increase its surface area exposed to the medium, promote the dissolution of the drug, increase the stability of the drug; it can also reduce the particle size, increase the distribution of the drug in the body, thereby improving the bioavailability of the drug. Therefore, nanomaterials have some excellent properties different from traditional materials. [0003] At present, small-molecule sheep placenta is widely used in cosmetics, but the permeability of many components contained in the small-molecule sheep placenta extracted by the current meth...

AI Technical Summary

Problems solved by technology

[0003] At present, small-molecule sheep placenta is widely used in cosmetics, but the permeability of many components contained in the small-molecule sheep placenta extracted by the current method needs to be further improved in the skin, and the peptides and active ingredients contained in it are extremely rare. Stable, easy to degrade, not easy to store at room temperature, and the small molecule sheep placenta solution is slightly yellow and viscous after freeze-drying, poor dispersibility, fishy smell, and slightly yellow in color

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