Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Traditional Chinese medicine powder injection preparation and preparation method thereof

A technology of traditional Chinese medicine powder and traditional Chinese medicine, which is applied in the direction of medical formula, drug combination, drug delivery, etc., and can solve problems such as increasing product stability

Active Publication Date: 2021-11-05
TIANJIN CHASE SUN PHARM CO LTD
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of traditional Chinese medicine powder injection preparation and preparation method thereof, solve the problem of removing polysorbate 80 to promote stability, increase product stability, overcome the Potential adverse reactions caused by the addition of polysorbate 80

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Traditional Chinese medicine powder injection preparation and preparation method thereof
  • Traditional Chinese medicine powder injection preparation and preparation method thereof
  • Traditional Chinese medicine powder injection preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] The invention provides a kind of preparation method of traditional Chinese medicine powder injection preparation, comprises the following steps:

[0019] The traditional Chinese medicine injection without polysorbate 80 is mixed with the supporting agent, and then the mixed solution is subjected to freezing treatment, sublimation drying treatment and analysis drying treatment in sequence.

[0020] The present invention does not have strict requirements on the source of the polysorbate-80-free traditional Chinese medicine injection. According to the formula of conventional Chinese medicine injection, polysorbate 80 in the formula of traditional Chinese medicine injection is removed, and the traditional Chinese medicine injection can be prepared by itself.

[0021] The preparation method of the traditional Chinese medicine powder injection preparation of the present invention is especially suitable for the Xuebijing injection without polysorbate 80, which solves the stabil...

Embodiment 1

[0058] Take 100g of safflower decoction pieces, add 8 times the amount of 30% ethanol to extract for 8 hours, filter out 4 to 6 times the amount of medicinal liquid, add 95% ethanol to make the alcohol content to 70%, and store it in a cold storage at 0 to 8°C for 48 hours. Filtrate, and concentrate the filtrate to 100mL under reduced pressure; add 95% ethanol to the concentrated solution to make the alcohol content to 80%, store in cold storage at 0-8°C for 48 hours, filter, recover ethanol from the filtrate, concentrate, and vacuum-dry to make safflower dry paste. The amount is 9.0g.

[0059] Take 100 g of Radix Paeoniae Rubra decoction pieces, add 10 times the amount of purified water, heat to boil, keep boiling slightly for two hours, filter, collect filtrate I, continue heating and boiling the medicinal residues with 8 times the amount of purified water, keep boiling slightly for one hour, discard the medicinal residues, Collect the filtrate II, combine the medicinal solu...

Embodiment 2

[0073] Take 100g of safflower decoction pieces, add 8 times the amount of 30% ethanol to extract for 8 hours, filter 4 to 6 times the amount of medicinal liquid, add 95% ethanol to make the alcohol content to 70%, and store it in a cold storage at 0-8°C for 48 hours. Filtrate, concentrate the filtrate to 100mL under reduced pressure; add 95% ethanol to the concentrated solution to make the alcohol content to 80%, store in cold storage at 0-8°C for 48 hours, filter, recover the ethanol from the filtrate, concentrate, and dry in vacuum to make safflower dry paste. The yield is 8.6g.

[0074] Take 100 g of Radix Paeoniae Rubra decoction pieces, add 10 times the amount of purified water, heat to boil, keep boiling slightly for two hours, filter, collect filtrate I, continue heating and boiling the medicinal residues with 8 times the amount of purified water, keep boiling slightly for one hour, discard the medicinal residues, Collect the filtrate II, combine the medicinal solutions...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of medicine production and particularly relates to a traditional Chinese medicine powder injection preparation and a preparation method thereof. A traditional Chinese medicine injection without polysorbate 80 is mixed with a supporting agent, freezing treatment, sublimation drying treatment and vacuum drying treatment are performed in sequence, such that a defect that product stability is poor after the polysorbate 80 is removed is overcome, the moisture content of the traditional Chinese medicine injection is reduced, an effect of retarding hydrolysis and oxidation of components is achieved, and product component stability is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine production, and in particular relates to a traditional Chinese medicine powder injection preparation and a preparation method thereof. Background technique [0002] Polysorbate 80, also known as: Tween 80 (tween 80 or Polysorbate 80), is a colorless, to light yellow or orange-yellow viscous liquid; slightly peculiar smell. The taste is slightly bitter and slightly astringent, with a sense of warmth. Soluble in water, ethanol, methanol or ethyl acetate, very slightly soluble in mineral oil. It is a kind of surfactant commonly used in liquid preparations. It is an oil / water emulsifier and can be used as a stabilizer, diffusing agent, antistatic agent, fiber lubricant, etc. It is prepared by the reaction of sorbitan monooleate and ethylene oxide. [0003] At present, polysorbate 80 is often added to traditional Chinese medicine injections in the market to improve the stability of active ingredie...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/19A61K36/65A61K36/71A61K47/10A61K47/26A61P7/00
CPCA61K9/19A61K9/0019A61K47/26A61K47/10A61K36/286A61K36/71A61K36/65A61K36/236A61K36/537A61K36/232A61P7/00A61K2300/00
Inventor 姚小青黎先军张海燕郑媛媛孙明珍张春涛潘勤
Owner TIANJIN CHASE SUN PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com