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Anti-inflammatory composition

A composition and compound technology, applied in anti-inflammatory agents, drug combinations, plant raw materials, etc., can solve problems such as increasing the incidence of cancer, infection, and increasing cytokine activity

Pending Publication Date: 2021-12-03
FERMENTATIONEXPERTS AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of blockade has some serious side effects some of which are infections such as tuberculosis, sepsis and fungal infections and possible increased incidence of cancer and still there is increased cytokine activity

Method used

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  • Anti-inflammatory composition
  • Anti-inflammatory composition
  • Anti-inflammatory composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Fermented plant materials, including fermented rapeseed species (rapeseed) and seaweed (Laminaria) combined methanol extracts (80% methanol)) for compound analysis.

[0106] Chromatography at Dionex Performed on a 3000 Quaternary Rapid Separation UHPLC+focusing system (Thermo Fisher Scientific, Gemmering, Germany).

[0107] On a Kinetex 1.7u XB-C18 column (100×2.1mm, 1.7μm, Separation was achieved on Phenomenex, Torrance, CA, USA. Formic acid (0.05%) and acetonitrile (provided with 0.05% formic acid) in water were used as mobile phases A and B, respectively.

[0108] Gradient conditions are as follows: 0.0-0.5min, 2% B; 0.5-14.0min 2-20% B; -26.55min 100-2%B and 26.55-30.0min 2%B. The mobile phase flow rate was 300 μl min-1. The column temperature was maintained at 25°C. Four wavelengths (205nm, 220nm, 250nm and 390nm) were monitored by a UV-VIS detector.

[0109] Liquid chromatography was coupled to a CompactmicrOTOF-Q mass spectrometer (Bruker, Bremen, Germa...

Embodiment 2

[0122] Preparation of composite plant material extracts

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Abstract

The present invention relates to a composition comprising a non-polar fraction obtained from at least one fermented plant material, wherein the at least one plant material has been subjected to a lactic acid fermentation.

Description

technical field [0001] The present invention relates to a composition obtained from fermented plant material, which has anti-inflammatory activity and is capable of inhibiting interleukin-12, interleukin-1β and / or interleukin-6 activity; and / or inhibiting tumor necrosis factor alpha (TNF-alpha or TNF- α) activity; and / or up-regulate interleukin-10, interleukin-1Ra, interleukin-4, interleukin-11, interleukin-13; or transforming growth factor beta (TGF-beta); by administering the composition to a mammal, the The composition can be used to prepare anti-inflammatory substances for treating, slowing down or preventing various diseases, including treating pathological conditions related to inflammation. Background technique [0002] Herbal medicine has been used to combat diseases and infections in humans and animals, and it has been demonstrated that plants include many components that have positive nutritional and pharmacological effects on human and animal organisms. Despite t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/03A61K36/31A61P29/00
CPCA61K36/31A61K36/03A61P29/00A61K2236/19A61K2300/00
Inventor 延斯·赫夫纳·莱加特
Owner FERMENTATIONEXPERTS AS