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Application of metformin in activation of female germline stem cells

A technology of reproductive stem cells and metformin, applied in the directions of application, organic active ingredients, medical preparations containing active ingredients, etc., to avoid abnormal glucose tolerance of PCOS, improve ovarian reserve function and follicle development process, and promote cell proliferation.

Pending Publication Date: 2021-12-17
NINGXIA MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Metformin is a classic drug for the treatment of obese type 2 diabetes. So far, there has been no report on the role of metformin in activating female reproductive stem cells and promoting their proliferation

Method used

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  • Application of metformin in activation of female germline stem cells
  • Application of metformin in activation of female germline stem cells
  • Application of metformin in activation of female germline stem cells

Examples

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Embodiment Construction

[0036] The embodiments will be described in detail hereinafter, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, the same numerals in different drawings refer to the same or similar elements unless otherwise indicated. The implementations described in the following examples do not represent all implementations consistent with this application. These are merely examples of systems and methods consistent with aspects of the present application as recited in the claims.

[0037] In the first aspect, the present application provides the application of metformin in activating female reproductive stem cells.

[0038] In the second aspect, the present application provides the application of metformin in the preparation of products for activating female reproductive stem cells.

[0039] In a third aspect, the present application provides the use of metformin in the preparation of products for preventi...

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Abstract

The invention discloses a novel application of metformin, namely, the metformin can activate female germline stem cells and promote proliferation of the female germline stem cells, so that follicular development disorder diseases such as polycystic ovarian syndrome and premature ovarian failure are improved; the invention discloses the application of the metformin to preparation of a medicine for activating the female germline stem cells and the application of the metformin to preparation of the medicine for preventing and / or treating the polycystic ovarian syndrome by activating the female germline stem cells. Experimental results prove that the metformin is applied to activation of the female germline stem cells. The metformin can activate the female germline stem cells, promote cell proliferation and improve an ovarian reserve function and a follicle development process. The metformin also can effectively improve abnormal PCOS glucose tolerance, weight gain, abnormal ovulation and polycystic ovarian lesion, and improves the polycystic ovarian syndrome by activating the female germline stem cells. According to the application of the metformin in activation of the female germline stem cells, evidence and basis are provided for directly utilizing the metformin to activate the generation and proliferation of the female germline stem cells.

Description

technical field [0001] The application relates to the technical field of metformin use, in particular to the application of metformin in activating female reproductive stem cells. Background technique [0002] Stem cells are ideal seed cells with the potential of self-renewal and multiple differentiation, and play a fundamental role in maintaining body homeostasis, cell regeneration and repair. Female germline stem cells (FGSCs), as one of many stem cells, exist in the surface epithelium of the ovary, and can differentiate into oocytes and promote follicle renewal. Previous studies have shown that female germline stem cells can be successfully isolated from postnatal mammalian ovaries, and at the same time, after transplantation of FGSCs, follicles at various stages can be restored and healthy offspring can be produced. Therefore, the proliferative ability of FGSCs contributes to the maintenance of follicular development and prolongation of the reproductive cycle. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/155A61P15/00A61P15/08A23L33/10
CPCA61K31/155A61P15/00A61P15/08A23L33/10A23V2002/00A23V2200/30
Inventor 何瑞吴际李广永马会明王春红孙亚群
Owner NINGXIA MEDICAL UNIV
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