Application of GCS inhibitor in preparation of medicine for treating cocaine addiction

An inhibitor, cocaine technology, applied in the direction of drug combination, pharmaceutical formulation, organic active ingredients, etc., can solve problems such as addiction, cocaine has not yet been seen, and achieve the reduction of dendritic spine density, inhibition of behavioral effects, and good application prospects. Effect

Active Publication Date: 2022-01-07
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on GCS and its inhibitors mainly focuses on the mechanism of tumor multidrug resistance, and there is no report on its relationship with cocaine addiction

Method used

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  • Application of GCS inhibitor in preparation of medicine for treating cocaine addiction
  • Application of GCS inhibitor in preparation of medicine for treating cocaine addiction
  • Application of GCS inhibitor in preparation of medicine for treating cocaine addiction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: GCS inhibitor treatment cocaine of the present invention causes pain

[0039] 1 experimental reagent

[0040] The reagents used in this section are as follows:

[0041] Cocaine Hydrochloride (National Institute for Food and Drug Control)

[0042] Normal saline (Sichuan Kelun Pharmaceutical Co., Ltd.)

[0043] RIPA lysate (Shanghai Biyuntian Biotechnology Co., Ltd., P0013B)

[0044] BCA kit (Shanghai Biyuntian Biotechnology Co., Ltd., P0010)

[0045] 5×SDS-PAGE Electrophoresis Loading Buffer (Shanghai Biyuntian Biotechnology Co., Ltd., P0015)

[0046] 7.5% SDS-PAGE reagent (Guangzhou Baihe Biotechnology Co., Ltd., PG111)

[0047] 10% SDS-PAGE reagent (Guangzhou Baihe Biotechnology Co., Ltd., PG112)

[0048] 12.5% ​​SDS-PAGE reagent (Guangzhou Baihe Biotechnology Co., Ltd., PG113)

[0049] Methanol (Shanghai Chemical Reagent Co., Ltd.)

[0050] Protein pre-stained marker (Thermo Scientific, 26616)

[0051] Tris-base (Solarbio, G8200)

[0052] Glyci...

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Abstract

The invention discloses application of a GCS inhibitor in preparation of a medicine for treating cocaine addiction, and belongs to the field of drug rehabilitation medicines. Experiments prove that the GCS inhibitor can specifically reduce the content of glucosylceramide sphingolipid in the nucleus-isolated brain region, reduce the dendritic branch number and the dendritic spine density, and effectively inhibit the behavioral effects (behavioral sensitization, reward effect and autonomous administration behavioral effect) of cocaine on mice. The GCS inhibitor is used for preparing the medicine for treating cocaine addiction, and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of detoxification drugs. Background technique [0002] Cocaine (Cocaine), also known as cocaine, is chemically called methylbenzoylecgonine. It is generally in the form of white crystals, odorless, bitter and numb. It was first used for local anesthesia and the treatment of asthma. The strongest natural central stimulant, which leads to abuse because of its excitatory effect on the central nervous system, and has become one of the world's main drugs since 1985. [0003] Cocaine addiction is a chronic recurrent brain disease that belongs to the category of drug dependence. Cocaine addiction can cause plastic changes in brain structure and function. Related brain regions include the nucleus accumbens, striatum, and frontal The cortex, hippocampus, and ventral tegmental area are also endangered in many ways, including mental decadence, personality defects, mental dysfunction, and corresponding infectious complications, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/4025A61P25/36
CPCA61K45/00A61K31/4025A61P25/36
Inventor 岑小波蒋林宏
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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