Leave-on oral care compositions

An oral care and composition technology, applied in the field of disposable oral care compositions, can solve the problems of lack of time to repair or even strengthen host tissue, limited residence time, etc., to achieve beneficial effects of improving wound healing, alleviating dry mouth, accelerating healing effect

Pending Publication Date: 2022-01-18
PROCTER & GAMBLE CO
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the brushing has a limited dwell time of 2 minutes, it leaves little time to repair or even strengthen the host tissue

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Leave-on oral care compositions
  • Leave-on oral care compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] Example 1: Examples A and B

[0121] Examples A and B are leave-on oral care gel compositions shown in Table 1 below, wherein the amounts of components are described in weight percent ("wt%"). The examples were prepared by conventional methods. Example A is a comparative gel composition containing sodium hyaluronate (as a source of hyaluronic acid) but no trehalose. Example B is the gel composition containing sodium hyaluronate and 10% by weight trehalose of the present invention.

[0122] Table 1: Examples A-B - Gel Compositions

[0123]

[0124] *Sodium hyaluronate with a weight average molecular weight of about 1,400,000 Da.

Embodiment 2

[0125] Example 2: Barrier Protection Test

[0126] The barrier protection test is described here. This test evaluates the barrier protective ability of a leave-on oral care composition by treating cells covered with a sample with capsaicin.

[0127] cell culture :

[0128] Human gingival epithelial (HGE) cells were maintained in a 37°C incubator, CO 2 Saturation is 5%. Dulbecco's Modified Eagle's Medium (DMEM, Gibco) was supplemented with 10 wt% fetal calf serum and 1 wt% penicillin-streptomycin to prepare a complete medium for these cells, which was changed every 2-3 days.

[0129] Barrier Protection Assay by Real-Time Cell Analyzer (RTCA) :

[0130] Barrier protection of samples was monitored using Impedance-based Real-Time Cell Analyzer (RTCA) xCELLigence RTCA DP (ACEABioscience Inc., San Diego, CA) equipment. Add 50ul of complete medium to the E-plate to get a background reading, then add 100ul of cell suspension. Incubate E-plates containing 28,000 cells / well ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to view more

Abstract

The invention discloses a leave-on oral care composition for promoting gum health, which comprises a hyaluronic acid and a gum-strengthening polyol.

Description

technical field [0001] The present invention relates to leave-on oral care compositions for promoting gum health in a user. In particular, such oral care compositions comprising hyaluronic acid and gum strengthening polyols can be used to provide improved barrier function / protection and sensory experience to the user. Background technique [0002] Gum diseases such as gingivitis and / or periodontitis cause acute and chronic inflammation of the gums in the oral cavity. "Gingivitis" is a milder form of the disease. Symptoms of gingivitis may include: bleeding gums; and red, swollen, or puffy gums. If left untreated, gingivitis can develop into "periodontitis." With periodontitis, the gums break away from the teeth and create spaces called "periodontal cavities," which can become infected with pathogenic bacteria. Bacteria exist as biofilms on tooth root surfaces. Bacteria in the biofilm may attack the gums and the underlying alveolar bone, which supports the teeth. These ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/60A61K8/73A61K8/44A61K8/365A61K8/34A61P1/02A61Q11/00
CPCA61K31/7016A61K31/355A61K31/197A61K31/728A61K31/375A61C19/063A61K9/0063A61K47/26A61K47/36A61K47/10A61Q11/00A61K8/735A61K8/345A61K8/86A61K8/8147A61K8/8176A61K8/602A61K2800/30A61K2800/87A61K2800/88A61K2800/884A61P1/02A61Q17/005A61K9/0053A61K8/676A61K8/678A61K8/673A61K8/60A61K47/32
Inventor R·斯特兰德苏旸史运明李潇潇王冠男
Owner PROCTER & GAMBLE CO
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap