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Application of medicine for treating chronic neurodegenerative diseases

A neurodegenerative and disease technology, applied in nervous system diseases, neuromuscular system diseases, drug combinations, etc., can solve the problems that do not involve citrate idenafil crystalline form and preparation method, etc., and achieve broad application prospects. Effect

Inactive Publication Date: 2022-02-11
刘桂坤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Chinese patent (application number 02100198.7) discloses edenafil and its preparation method, etc., but does not involve the crystal form of edenafil citrate and its preparation method

Method used

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  • Application of medicine for treating chronic neurodegenerative diseases
  • Application of medicine for treating chronic neurodegenerative diseases
  • Application of medicine for treating chronic neurodegenerative diseases

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Embodiment Construction

[0018] In order to facilitate the understanding of those skilled in the art, the present invention will be further described below in conjunction with the examples, and the contents mentioned in the embodiments are not intended to limit the present invention.

[0019] Pharmacodynamic test 1:

[0020] (1) Experimental materials

[0021] 1. Experimental animals and grouping

[0022] (1) Experimental animals

[0023] Kunming mice, male, with an initial weight of 20±2g, were provided by the Experimental Animal Center of Dalian Medical University, certificate number: SCXK (Liao) 2008-0002.

[0024] (2) Feeding conditions

[0025] Raised in an SPF grade environment, the temperature was maintained at 22°C±3°C, the humidity was 50%, and light and dark were alternated for 12 hours.

[0026] (3) Grouping of experimental animals

[0027] After the mice were fed for 3 days, the mice were divided into groups using the random number table method: blank control group, model group, alden...

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Abstract

The invention relates to application of 1-[3-(6, 7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4, 3-d] pyrimidine-5-yl)-4-ethoxy benzenesulfonyl]-cis-3, 5-dimethylpiperazine citrate or Aildenafil citrate in preparation of a medicine for treating neurodegenerative diseases, wherein the treatment of chronic neurodegenerative diseases comprises the treatment of Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and different types of spinal cerebellar ataxia medicine diseases. The Aildenafil citrate has a wide application prospect in preparation of the medicine for treating the neurodegenerative diseases and treatment of the neurodegenerative diseases.

Description

technical field [0001] The present invention relates to 1-[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)- The use of 4-ethoxybenzenesulfonyl]-cis-3,5-dimethylpiperazine citrate (Aildenafil citrate), used for the manufacture and treatment of chronic neurodegenerative diseases, Including the application of drugs in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), and different types of spinocerebellar ataxia (SCA). Background technique [0002] Neurodegenerative diseases are caused by the loss of neurons and / or their myelin sheath, which worsens and becomes dysfunctional over time. The pathogenic factors of neurodegenerative diseases are diverse, such as oxidative stress, mitochondrial dysfunction, immune inflammation, etc., and the advantages of multi-channel and multi-target treatment can play a significant role in improving the symptoms of patients with neurodegenerative diseases ...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61P25/28A61P25/16A61P25/14A61P25/00A61P21/00
CPCA61K31/519A61P25/28A61P25/16A61P25/14A61P25/00A61P21/00
Inventor 刘桂坤
Owner 刘桂坤
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