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Extraction process for optimizing berberine hydrochloride in cortex phellodendri chinensis decoction pieces

A technology of berberine hydrochloride and extraction process, which is applied in the field of optimizing the extraction process of berberine hydrochloride in Chuan Phellodendron decoction pieces, can solve the problems of slow weighing speed, low extraction rate, and low extraction efficiency, and reduce the proportion Error, Enzyme Activity Improvement, Sufficient Extraction Effect

Pending Publication Date: 2022-03-25
SICHUAN ACAD OF FORESTRY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Current berberine extraction methods mainly include: dilute sulfuric acid method, milk of lime method and ethanol leaching method, wherein, the dilute sulfuric acid method mainly utilizes the sulfate in berberine to dissolve in acidic solution, and first converts berberine into Sulfate is dissolved in acid, then added with hydrochloric acid and then converted into hydrochloride for precipitation. The advantage is that the material is cheap and the process is simple. However, during the extraction process, the ratio of solid to liquid is single, and it is inconvenient to carry out simultaneous extraction of raw materials with multiple groups of solid to liquid ratios. Processing, the extraction rate is low, and the material-liquid ratio is usually manually weighed and then proportioned. Manual weighing is not only low in accuracy, but also slow in weighing speed and low in extraction efficiency.

Method used

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  • Extraction process for optimizing berberine hydrochloride in cortex phellodendri chinensis decoction pieces
  • Extraction process for optimizing berberine hydrochloride in cortex phellodendri chinensis decoction pieces
  • Extraction process for optimizing berberine hydrochloride in cortex phellodendri chinensis decoction pieces

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Effect test

Embodiment 1

[0033] A process for optimizing the extraction of berberine hydrochloride in Chuan Phellodendron decoction pieces, comprising the following steps:

[0034] S1. Take the decoction pieces of Phellodendron Phellodendri, air-dry naturally, sieve the pulverized powder, and mix dilute sulfuric acid, β-glucanase and cellulase with water, and set aside;

[0035] S2. Put the Phellodendron sichuan powder and sulfuric acid in step 1 into the feeding device respectively, and the feeding device divides the Phellodendron sichuan powder and the mixed solution into three groups, add them to different extraction tanks, and reflux extraction;

[0036] S3. After reflux extraction, let cool at room temperature and soak, extract the residue, and repeat the above steps for the filter residue to process again;

[0037] S4. Combine all filtrates, concentrate, adjust pH with dilute hydrochloric acid; cool, add saturated NaCl solution, store overnight at 4°C, filter with suction, and dry to obtain the ...

Embodiment 2

[0044] A process for optimizing the extraction of berberine hydrochloride in Chuan Phellodendron decoction pieces, comprising the following steps:

[0045] S1. Take the decoction pieces of Phellodendron Phellodendri, air-dry naturally, sieve the pulverized powder, and mix dilute sulfuric acid, β-glucanase and cellulase with water, and set aside;

[0046] S2. Put the Phellodendron sichuan powder and sulfuric acid in step 1 into the feeding device respectively, and the feeding device divides the Phellodendron sichuan powder and the mixed solution into three groups, add them to different extraction tanks, and reflux extraction;

[0047] S3. After reflux extraction, let cool at room temperature and soak, extract the residue, and repeat the above steps for the filter residue to process again.

[0048] S4. Combine all filtrates, concentrate, adjust pH with dilute hydrochloric acid; cool, add saturated NaCl solution, store overnight at 4°C, filter with suction, and dry to obtain the ...

Embodiment 3

[0055] see Figure 1-Figure 8 , a process for optimizing the extraction of berberine hydrochloride in Chuan Phellodendron decoction pieces, comprising the following steps:

[0056] S1. Take the decoction pieces of Phellodendron Phellodendri, air-dry naturally, sieve the pulverized powder, and mix dilute sulfuric acid, β-glucanase and cellulase with water, and set aside;

[0057] S2. Put the Phellodendron sichuan powder and sulfuric acid in step 1 into the feeding device respectively, and the feeding device divides the Phellodendron sichuan powder and the mixed solution into three groups, add them to different extraction tanks, and reflux extraction;

[0058] S3. After reflux extraction, let cool at room temperature and soak, extract the residue, and repeat the above steps for the filter residue to process again.

[0059] S4. Combine all filtrates, concentrate, adjust pH with dilute hydrochloric acid; cool, add saturated NaCl solution, store overnight at 4°C, filter with sucti...

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Abstract

The invention relates to the technical field of cortex phellodendri chinensis extraction, and provides an extraction process for optimizing berberine hydrochloride in cortex phellodendri chinensis decoction pieces, the extraction process for optimizing berberine hydrochloride in the cortex phellodendri chinensis decoction pieces comprises the following steps: taking the cortex phellodendri chinensis decoction pieces, naturally air-drying, and sieving the crushed powder to obtain berberine hydrochloride powder; adding water into dilute sulphuric acid, beta-glucanase and cellulase, and mixing for later use; respectively loading the cortex phellodendri chinense powder in the step 1 and sulfuric acid into a feeding device, adding into different extraction tanks, and carrying out reflux extraction; combining all filtrates, concentrating, and adjusting the pH with diluted hydrochloric acid; and cooling, adding a saturated NaCl solution, preserving overnight at 4 DEG C, carrying out suction filtration, and drying. According to the optimized extraction process for berberine hydrochloride in cortex phellodendri chinensis decoction pieces, the enzyme activity is improved through dilute sulphuric acid, plant cell walls are thoroughly damaged by beta-glucanase and cellulase, effective components are extracted more sufficiently, and therefore the effects of being capable of accelerating extraction, sufficient in extraction and high in extraction rate are achieved.

Description

technical field [0001] The invention relates to the technical field of Phellodendron sichuanensis extraction, in particular to an extraction process for optimizing berberine hydrochloride in decoction pieces of Phellodendron sichuanensis. Background technique [0002] The scientific name of Phellodendron sichuanensis is Phellodendron sichuanensis, which is an arbor plant of the genus Phellodendri in Rutaceae. The bark is cracked, there is no cork layer, the inner layer is yellow, sticky, the branchlets are thick, smooth and glabrous, and the singular pinnate compound leaves are opposite and oblong-shaped. Needle-shaped to oblong-ovate, unisexual flowers, dioecious, arranged in terminal panicles, berry-like drupes spherical, dense, black, nuclear, the bioactive components of Phellodendron sichuanensis except extracts and total alkaloids , the main active ingredient is berberine hydrochloride, because of its good steaming effect, it is widely used in clinical practice. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D455/03B01D11/02
CPCC07D455/03B01D11/0288
Inventor 孙志鹏罗建勋王刚王勇吴焦焦蒲尚饶
Owner SICHUAN ACAD OF FORESTRY
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