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Traditional Chinese medicine composition for treating hypertension and preparation method thereof

A technique for hypertension and composition, which is applied in the field of traditional Chinese medicine composition for treating hypertension and its preparation field, can solve problems such as unsatisfactory treatment effect of antihypertensive western medicine, and achieve reversal of left ventricular hypertrophy of heart, reduction of mass index, chemical composition, etc. stable effect

Active Publication Date: 2022-03-29
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in fact, the treatment effect of antihypertensive western medicine is not ideal, only 39% of hypertensive patients achieve the treatment goal of blood pressure lower than 140 / 90mmHg

Method used

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  • Traditional Chinese medicine composition for treating hypertension and preparation method thereof
  • Traditional Chinese medicine composition for treating hypertension and preparation method thereof
  • Traditional Chinese medicine composition for treating hypertension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] According to the orthogonal experimental design method L 18 (3 6 ) to screen each raw material ratio, with 6 traditional Chinese medicines as 6 factors, each factor is provided with 3 levels of different doses, the six factors and three levels of orthogonal design table are shown in Table 1, a total of 18 test groups, each group dosage See Table 2.

[0045] Table 1 Orthogonal design table with six factors and three levels

[0046]

[0047] Table 2 Orthogonal experimental design L 18 (3 6 )test group

[0048]

[0049] Each group is used for the preparation steps of the Chinese medicine composition of treating hypertension as follows:

[0050] Step (1): mix the weighed salvia miltiorrhiza, kudzu root, eucommia ulmoides, prunella vulgaris, and achyranthes bidentata with an ethanol aqueous solution with a volume fraction of 80% according to the ratio of solid to liquid 1g:10mL, and soak for 0.5h;

[0051] Step (2): Heat and reflux the soaked Salvia miltiorrhiza,...

Embodiment 2

[0061] 18 groups of traditional Chinese medicine compositions for the treatment of hypertension prepared in Example 1 and the water decoction prepared in Group 1 of Comparative Example were evaluated for their therapeutic effect on high-salt-induced hypertension model rats

[0062] 1. Test animals

[0063] SD (Sprague Dawley) rats, male, SPF grade, body weight (160-180g), a total of 140, were purchased from Liaoning Changsheng Biotechnology Co., Ltd., bred in the Experimental Animal Center of Heilongjiang University of Traditional Chinese Medicine, license number SYXK (black ) 2018-007. Animals in this study were approved by the Animal Ethics Committee of Heilongjiang University of Traditional Chinese Medicine, approval number 2020031203.

[0064] 2. Method

[0065] 2.1 Model preparation

[0066] The high-salt-induced hypertension model was prepared from SD rats. The blank group was fed with conventional feed, and the model group and experimental groups 1-18 were fed with 8...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating hypertension and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating hypertension comprises the following raw materials in parts by weight: 10-25 parts of uncaria rhynchophylla, 15-25 parts of salvia miltiorrhiza, 15-30 parts of radix puerariae, 5-15 parts of eucommia ulmoides, 5-15 parts of selfheal and 10-20 parts of achyranthes bidentata. The uncaria is used for calming the liver, suppressing yang and calming endogenous wind; radix salviae miltiorrhizae and radix puerariae are used for promoting blood circulation to remove blood stasis and dredging blood vessels; eucommia ulmoides is used for tonifying liver and kidney to prevent injury to liver yin; the selfheal is used for clearing liver-fire, removing stasis and diminishing swelling; the radix achyranthis bidentatae is used for removing blood stasis, stimulating the menstrual flow, guiding the downward flow of blood and tonifying the liver and kidney. All the components act together to achieve the effect of treating hypertension. Meanwhile, the invention also provides a preparation method of the traditional Chinese medicine composition, the disclosed preparation method is simple to operate, the quality control is easy in the production process, and the chemical components of the prepared traditional Chinese medicine composition are stable.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension, traditional Chinese medicine belongs to the category of "dizziness", "headache", etc. Cardiovascular and cerebrovascular disease deaths account for more than 40% of the total death toll, and hypertension is one of the most important risk factors of cardiovascular and cerebrovascular diseases. Hypertension refers to a clinical syndrome characterized by increased systemic arterial blood pressure (systolic blood pressure (SBP) ≥ 140 mmHg, diastolic blood pressure (DBP) ≥ 90 mmHg), which may be accompanied by functional or organic damage to the heart, brain, kidneys and other organs. sign. The onset of high blood pressure is generally slow. The common symptoms are dizziness, headache, neck tightness, fatigue, palpita...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P9/12
CPCA61K36/74A61K36/537A61K36/488A61K36/46A61K36/536A61K36/21A61P9/12A61K2236/333A61K2236/39A61K2300/00
Inventor 卢芳刘树民刘涵星沙迪付佳琪王天雨袁晋
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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