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Determination method for withdrawal period of aquatic animals in production state

An aquatic animal and determination method technology, which is applied in chemical instruments and methods, measuring devices, material separation and other directions, can solve the problems of uneven amount of drugs, great difficulty in calculation, etc., and achieve the effect of simple and accurate method.

Pending Publication Date: 2022-04-19
YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this state, the amount of drug ingested by each fish is not uniform and has certain differences, which will lead to large differences in the concentration of drug residues among individuals, making the calculation of drug withdrawal period very difficult

Method used

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  • Determination method for withdrawal period of aquatic animals in production state
  • Determination method for withdrawal period of aquatic animals in production state
  • Determination method for withdrawal period of aquatic animals in production state

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Experimental program
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Effect test

Embodiment 1

[0030] 1. Experimental animals

[0031] 54 bream, without any disease, were purchased from the experimental base of the Yangtze River Fisheries Research Institute of the Chinese Academy of Fishery Sciences, with an average weight of 461.5±52.3g. The test water is continuously aerated with oxygen by an oxygen pump to keep the dissolved oxygen in the water greater than 4.8mg / L, the pH is 7.2-7.8, and the temperature is 25±0.5°C. Before the test, the fish were placed in a glass aquarium for one week and fed with a blank full-price feed (without any drugs).

[0032] 2. Drugs and reagents

[0033] Drugs: Mebendazole powder was purchased from Hubei Aibo Technology Co., Ltd., with a content greater than 98%;

[0034] Standard deuterated mebendazole (MBZ-d 3 ), mebendazole (MBZ), aminomethbendazole (MBZ-NH 2 ) and hydroxymebendazole (MBZ-OH) were purchased from Dr.Ehrenstorfer Company in Germany, and the content was greater than 99%.

[0035] Reagent:

[0036] Anhydrous magnesiu...

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Abstract

The invention discloses a method for determining the withdrawal period of aquatic animals in a production state, and relates to the technical field of aquatic drug residues. The method specifically comprises the steps that the aquatic animals are subjected to insect-resistant drug (antibiotic) administration according to an actual production state method, then tissue collection is conducted, and the number of collection time points is not less than 5, and the collection time points comprise the time points lower than the maximum residual limit of insect-resistant drugs (antibiotic) and metabolites; the collected tissue is pretreated, and then the residual quantity of the medicine and metabolites of the medicine is detected; performing data inspection, eliminating abnormal values, calculating 95% percentile of each collection tissue in 95% confidence interval by using software WT1.4, setting the time lower than the maximum residual limit as the withdrawal period of each collection tissue, and determining the maximum value as the withdrawal period of the aquatic animals; the insect-resistant drug is mebendazole, and metabolites of the insect-resistant drug are hydroxymebendazole and aminomebendazole. The method can realize calculation of the withdrawal period of the aquatic animals in the production state, is simple and accurate, and has important popularization and application values.

Description

technical field [0001] The invention relates to the technical field of aquatic drug residues, in particular to a method for measuring drug withdrawal periods of aquatic animals under production conditions. Background technique [0002] At present, anti-insect drugs and antibiotics are one of the important treatments for aquatic animal parasites and bacterial diseases. However, after the drugs enter the body of aquatic animals, they will accumulate and may threaten human food safety and health through the food chain. In order to reduce the harm of drug residues to humans, the residual concentration must be reduced below the maximum limit, so there is a period of drug withdrawal after administration, which is called drug withdrawal period. [0003] In actual production conditions, group administration is generally carried out through the total weight of aquatic animals. In this state, the amount of drug ingested by each fish is not uniform and has certain differences, which w...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/08G01N30/32G01N30/34G01N30/72G01N30/86G01N1/04B01J20/281
CPCG01N30/02G01N30/06G01N30/08G01N30/32G01N30/34G01N30/7266G01N30/8679G01N1/04G01N2030/045G01N2030/062G01N2030/065G01N2030/324
Inventor 胥宁艾晓辉刘永涛董靖杨移斌周顺杨秋红
Owner YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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