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Preparation method of multi-mode rhenium disulfide diagnosis and treatment agent

A rhenium disulfide, multimodal technology, applied in the field of medical diagnosis and treatment agents, can solve the problems of complex synthesis process, increase the pressure of human metabolism, difficult size and morphology, and achieve good water solubility, increase drug efficacy, and prolong the body. half-life effect

Pending Publication Date: 2022-04-22
SUZHOU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the synthesis process of such nanosystems is usually complicated, and its size and shape are often difficult to control accurately, which may also increase the pressure on human metabolism.

Method used

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  • Preparation method of multi-mode rhenium disulfide diagnosis and treatment agent
  • Preparation method of multi-mode rhenium disulfide diagnosis and treatment agent
  • Preparation method of multi-mode rhenium disulfide diagnosis and treatment agent

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Embodiment 1

[0029] Embodiment 1: A method for preparing a multimodal rhenium disulfide diagnostic agent, comprising the following steps:

[0030] Step 1, the Br 2 , Re with a purity of 99.99%, and S with a purity of 99.999% were placed in a quartz tube respectively, wherein the ratio of the amount of Re to S was 1:2, and the quartz tube was placed in a three-temperature zone tube furnace, and the quartz tube Vacuum to 10 -4 Seal the tube after Pa, set the temperature of the growth zone to 1000°C, and set the temperature gradient between 1050 and 1000°C to achieve an optimal diffusion gradient. Under the above conditions, single crystal growth starts, and after the growth lasts for 6 days, it is naturally cooled to room temperature, and finally a block ReS with a size of 1 cm and a thickness of about 50 μm with metallic luster can be obtained. 2 ;

[0031] Step 2: Take 10 mg of the above ReS with a micro balance 2 Single crystal, put it in a corundum mortar and grind it into powder. P...

Embodiment 2

[0035] Embodiment 2: a rhenium disulfide nano-diagnostic agent, obtained by the following steps:

[0036] Step 1, the Br 2 , Re with a purity of 99.99%, and S with a purity of 99.999% were placed in a quartz tube respectively, wherein the ratio of the amount of Re to S was 1:2, and the quartz tube was placed in a three-temperature zone tube furnace, and the quartz tube Vacuum to 10 -4 Seal the tube after Pa, set the temperature of the growth zone to 1000°C, and set the temperature gradient between 1050 and 1000°C to achieve an optimal diffusion gradient. Under the above conditions, single crystal growth starts, and after the growth lasts for 6 days, it is naturally cooled to room temperature, and finally a block ReS with a size of 1 cm and a thickness of about 50 μm with metallic luster can be obtained. 2 ;

[0037] Step 2: Take 10 mg of the above ReS with a micro balance 2 Single crystal, put it in a corundum mortar and grind it into powder. Prepare 9 mol / L nitric acid s...

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Abstract

The invention discloses a preparation method of a multi-mode rhenium disulfide diagnosis and treatment agent, which comprises the following steps: respectively putting liquid bromine, rhenium and sulfur into a quartz tube, and heating to obtain blocky single crystal ReS2; the preparation method comprises the following steps: grinding blocky single crystal ReS2 into powder, and mixing the powder with a nitric acid solution to form a mixed solution; the mixed solution is stirred and then centrifuged, a sample is cleaned, and a ReS2 micron layer with magnetism is obtained; dispersing the obtained ReS2 micron layer into a mixed solution of N-methyl pyrrolidone and ethanol, centrifuging and cleaning to obtain a ReS2 nano layer; the obtained ReS2 nano layer and an mPEG-NH2 solution are mixed, stirred and dried, and the mPEG-NH2 modified ReS2 nano layer is obtained. The diagnosis and treatment agent obtained by the invention not only improves the definition and sensitivity of human soft tissue imaging, but also has good photo-thermal and magnetothermal characteristics, also improves the biocompatibility with human tissues, prolongs the in-vivo half-life period, and reduces the immunogenicity.

Description

technical field [0001] The invention relates to the technical field of medical diagnostic and therapeutic agents, in particular to a preparation method of a multimodal rhenium disulfide diagnostic and therapeutic agent. Background technique [0002] Cancer is a major killer that threatens human life, and its morbidity and mortality are increasing. It is estimated that 21 million people will suffer from cancer by 2030. At present, surgery, radiotherapy and chemotherapy are still the main means of clinical treatment of cancer. These methods often have large side effects and unsatisfactory therapeutic effects. The development of nanotechnology in the field of medicine has brought unprecedented opportunities for cancer treatment. A variety of novel nanotherapeutics have been developed to fight cancer. [0003] Generally, although each diagnosis and treatment mode of the nanosystem has its own unique advantages, it is also accompanied by certain limitations. For example, CT ca...

Claims

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Application Information

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IPC IPC(8): A61K49/12A61K41/00A61K47/60A61P35/00G01Q60/24G01N21/65B82Y5/00B82Y40/00
CPCA61K49/126A61K41/0052A61K47/60A61P35/00G01Q60/24G01N21/65B82Y5/00B82Y40/00
Inventor 钱睿琳吴淑毅张金磊马春兰季鸿田瞿灿煜
Owner SUZHOU UNIV OF SCI & TECH
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