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System and method for detecting clinical results of patients with hepatocellular carcinoma by HBV (Hepatitis B Virus)

A hepatocellular carcinoma, clinical outcome technology, applied in the medical field, to achieve the effect of reducing the detection of redundant or unrelated gene sequences

Inactive Publication Date: 2022-04-29
林根琼
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the detection system only judges the risk of recurrence through phenotypic changes. The risk of misjudgment of such results is high. Once the high risk of recurrence is judged, it will bring great psychological pressure to the patient.

Method used

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  • System and method for detecting clinical results of patients with hepatocellular carcinoma by HBV (Hepatitis B Virus)
  • System and method for detecting clinical results of patients with hepatocellular carcinoma by HBV (Hepatitis B Virus)
  • System and method for detecting clinical results of patients with hepatocellular carcinoma by HBV (Hepatitis B Virus)

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Experimental program
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Embodiment 1

[0029]In the prior art, the cancer treatment of cancer patients is not only surgery and radiotherapy and chemotherapy, but also many targeted drugs and immunotherapy drugs can be used. When cancer patients take targeted drugs and immunotherapy drugs, different patients have different gene mutation sites. Therefore, compared with indiscriminate attacks on cells and tissues in patients with radiotherapy and chemotherapy, personalized and precise treatment can make the disease more curable. Less physical damage achieves better healing results. The disease phenotype of liver cancer caused by the influence of HBV is affected by multiple cross-connected network pathways in the patient, and multiple genes are distributed on a single network pathway. For the molecular level detection of liver cancer, the amount of direct gene sequencing is very large. Based on this, the present invention uses aggregation detection of abnormal expression at the mRNA level, and obtains the most relevan...

Embodiment 2

[0059] This embodiment is a further improvement on Embodiment 1, and repeated content will not be repeated here.

[0060] A HBV detection system for the clinical results of patients with hepatocellular carcinoma, including a sample detection module, a data processing module and a data presentation module, such as image 3 shown.

[0061] The sample detection module can obtain the transcriptome sequencing result of the tissue sample by detecting the tissue sample at the transcriptome level. Preferably, the sample detection module is capable of detecting sequences and expression levels at DNA, RNA and protein levels.

[0062] The data processing module includes a processor and memory components, which are used to receive and process received data, and the data processing steps include:

[0063] (1) First-level screening: Qualitatively / quantitatively evaluate or / and compare transcriptome sequencing based on the functional annotation nodes on the physiological and metabolic path...

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Abstract

The invention relates to a method for detecting a clinical result of a hepatocellular carcinoma patient by HBV (Hepatitis B Virus). Qualitative / quantitative evaluation or / and comparison is carried out on the basis of known functional annotation nodes on physiological metabolic pathways for diagnosing liver cancer types and obtained by transcriptome sequencing; a plurality of genes irrelevant to or redundant to the biological function of the diagnosed liver cancer type are excluded after function enrichment clustering to obtain a first group of differential gene subsets after first screening; the voucher used as the comparison opposite direction for excluding the gene or the gene subset in the first screening is the first voucher. The first credential can exist in a first gene library, and is characterized by having no contribution to the generation of a target disease or having weak correlation with physiological pathways involved in the generation of disease phenotypes.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method and system for detecting the clinical results of HBV on hepatocellular carcinoma patients. Background technique [0002] Liver cancer has become the fourth leading cause of cancer-related death in the world, among which hepatocellular carcinoma (Hepatocellular carcinoma, HCC) accounts for about 85%-90% of primary liver malignancies, and its main cause is hepatitis B virus (HBV) and Chronic infection with hepatitis C virus (HCV), as well as alcoholism and metabolic syndrome. [0003] Despite the success of direct antiviral therapy in curing chronic hepatitis C, current antiviral therapy can only reduce rather than eliminate HBV. It is estimated that 292 million people are infected with HBV worldwide, and in China, HBV-associated HCC accounts for about 85% of the total HCC cases. [0004] Based on the influence of HBV on the incidence and prognosis of liver cancer, chan...

Claims

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Application Information

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IPC IPC(8): G16B20/30G16B20/50G16B25/10G16B30/10
CPCG16B20/50G16B20/30G16B25/10G16B30/10
Inventor 林根琼
Owner 林根琼
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