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Composite liposome for improving brain cognitive memory and neuroinflammation and preparation method thereof

A neuroinflammation, liposome technology, applied in the directions of liposome delivery, nervous system diseases, medical preparations of inactive ingredients, etc., can solve the problems of low stability, weakened efficacy, high pharmacokinetic differences, etc. Achieve the effects of inhibiting activation, reducing ROS production, improving brain cognitive memory and neuroinflammation

Active Publication Date: 2022-05-13
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both curcumin and EGCG exhibit resistance to iron-induced toxicity and have been shown to be synergistic in health promotion, but curcumin and EGCG have lower stability and higher pharmacokinetic differences, thereby weakening the its efficacy

Method used

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  • Composite liposome for improving brain cognitive memory and neuroinflammation and preparation method thereof
  • Composite liposome for improving brain cognitive memory and neuroinflammation and preparation method thereof
  • Composite liposome for improving brain cognitive memory and neuroinflammation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0046] Preparation method of liposome loaded with curcumin and EGCG

[0047] Egg yolk phospholipids (4 mg / mL), cholesterol, Tween 80 and curcumin (0.2 mg / mL) were dissolved in a mixed solvent of chloroform and ethanol (the volume ratio of the two was 2:1) by thin film ultrasonic method, wherein, The mass ratio of phospholipids to cholesterol is 6:1; the mass ratio of phospholipids to Tween 80 is 10:3. The obtained solution was transferred to a round-bottomed flask, and the solvent was evaporated to dryness using a rotary evaporator, and the sample was placed in a vacuum drying oven overnight to completely evaporate the organic reagent. EGCG aqueous solution (0.2 mg / mL) was added to the obtained sample, hydrated by rotary steaming for 40 minutes, and the obtained solution was placed in an ultrasonic cell disruptor for 15 minutes to disperse the system to obtain a uniformly dispersed liposome solution. Use a 0.22 μm filter membrane to filter to remove unencapsulated polyphenols...

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Abstract

The invention discloses a composite liposome for improving brain cognitive memory and neuroinflammation and a preparation method thereof, and belongs to the technical field of liposome preparation. According to the invention, a liposome capable of simultaneously loading a hydrophobic substance curcumin and a hydrophilic substance epigallocatechin gallate (EGCG) is prepared, on the basis, lactoferrin is utilized to carry out surface modification on the liposome, and hyaluronic acid is adopted to further stabilize the system through electrostatic interaction. The composite liposome obtained by the method has good stability and free radical scavenging efficiency, can significantly inhibit cognitive impairment induced by lipopolysaccharide, and is used for improving brain cognitive memory and neuroinflammation.

Description

technical field [0001] The invention relates to the technical field of liposome preparation, in particular to a composite liposome for improving brain cognitive memory and neuroinflammation and a preparation method thereof. Background technique [0002] With the change of human life style, neurological diseases have become a threat to human health. Neuroinflammation is a key pathological event that triggers and sustains neurodegenerative processes associated with many neurological diseases. Research has shown that natural ingredients in foods have shown great potential in alleviating neurological disorders. [0003] Curcumin is a hydrophobic polyphenol extracted from the rhizome of turmeric. It has biological and pharmacological activities such as antioxidant and anti-inflammatory. It can reduce the occurrence and development of Alzheimer's disease by inhibiting the combination of NF-κB and amyloid plaques. . Epigallocatechin gallate (EGCG) is a water-soluble polyphenol t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/61A61K47/64A61K31/353A61P25/28A61P25/00A61P29/00A61P39/06A61K31/12
CPCA61K47/6911A61K47/644A61K47/61A61K31/12A61K31/353A61P25/28A61P25/00A61P29/00A61P39/06A61K2300/00Y02A50/30
Inventor 刘夫国徐文浛马德雪王玉堂刘学波
Owner NORTHWEST A & F UNIV
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