177Lu-loaded degradable polymer material microsphere as well as preparation method and application thereof
A polymer material and microsphere technology, which is applied in the field of degradable polymer material microspheres and their preparation, can solve the problems of difficult degradation, nuclide imaging, and high specific gravity of 90Y microspheres, achieving good stability and small specific gravity Effect
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[0050] A biodegradable polymer material microsphere loaded with 177Lu, which is chitosan layer, 177Lu labeled polypamine layer and polydopamine blocking layer from the inside to the outside.
[0051] The preparation method of the degradable polymer material microspheres described in the present embodiment, comprising the following steps:
[0052] S1, the preparation of chitosan microsphere suspension by emulsified crosslinking method;
[0053] S11, to 20mL liquid paraffin, add 2mL span-80 solution dropwise, stir well for 30 minutes, to obtain solution A;
[0054] Step S11, span-80, may also be replaced with tween-20 solution or sodium dodecylbenzenesulfonate solution, span-80 solution dosage may be 0.1 ~ 4mL, but the present embodiment in the actual operation of the use of 2mL span-80 solution, does not mean that only 2mL span-80 solution can be selected, the same reason, the stirring time is not limited to 30 minutes, but the present embodiment stirred for 30 minutes in actual op...
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