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Medicine for treating atherosclerosis and application thereof

A technology of atherosclerosis and drugs, which is applied in the field of medicine and biology, can solve the problems of insignificant effect and reduction of aortic atherosclerotic plaque lesions, and achieve the effect of weight control

Active Publication Date: 2022-05-31
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The experimental results showed that compared with the model group, berberine, coptisine and palmatine could significantly reduce TC, TG and LDL-C, and the TC of the three decreased by 35.6%, 32.5%, and 26.8%, respectively, and the TG 51.5%, 53.1%, 47.6%, LDL-C decreased by 39.2%, 42.3%, 26.7%; pathological results showed that the degree of aortic atherosclerotic plaque can be significantly reduced, Coptidis alkaloids can inhibit HMG-COA effect, but the effect is not significant
[0010] Although the prior art has reported that some active monomers of traditional Chinese medicine can show the activity of treating atherosclerosis, there is still room for further improvement in its therapeutic effect

Method used

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  • Medicine for treating atherosclerosis and application thereof

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Experimental program
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Effect test

Embodiment 1

[0026] 1. Materials

[0027] 1.1 Experimental animals

[0028] SPF grade 5-6 weeks old male ApoE - / - 84 mice and 12 SPF grade 5-6-week-old male C57 mice (supplied by Beijing Weitong Lihua Laboratory Animal Co., Ltd.). Mice were kept in separate cages in a ventilated environment. Rat cages, bedding, drinking water and other breeding equipment should be strictly disinfected before use. The laboratory temperature was maintained at around 25±1°C. Relative humidity: 50-60%. All mice had free access to food and water. The indoor lighting is manually controlled to maintain a 12h alternating cycle of light and dark.

[0029] 1.2 Experimental drugs

[0030] Jatrorrhizine hydrochloride is extracted with reference to CN101695518A, its purity is 97wt%, and it is prepared to 0.4mg·mL with normal saline -1 The solution.

[0031] Simvastatin tablets (manufactured by Hangzhou Merck & Co., Ltd.), according to the maximum clinical dose of simvastatin in humans is 40 mg, and the same me...

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Abstract

The invention relates to a medicine for treating atherosclerosis and application of the medicine. The medicine comprises simvastatin and jatrorrhizine or a combination of pharmaceutically acceptable salts of the simvastatin and the jatrorrhizine, wherein the weight ratio of the simvastatin to the jatrorrhizine is 1: (1-5). The simvastatin and jatrorrhizine hydrochloride are combined according to a certain proportion, so that the weight can be controlled, and the TC, TG, LDL and HDL-C levels of atherosclerotic mice can be synergistically regulated.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and in particular relates to a medicine for treating atherosclerosis and use thereof. Background technique [0002] Atherosclerosis, a chronic inflammatory disease affecting large and medium-sized arteries, has been the main pathogenic factor of cardiovascular disease (CVD). Cardiovascular disease is now the number one cause of death in the world. An estimated 17.3 million people died from the disease in 2013, accounting for one-third of all global deaths. The key factors associated with maintaining cardiovascular health are smoking cessation, exercise, healthy diet, and maintaining normal levels of blood lipids, blood pressure, blood sugar, and body weight. Epidemiology says that adherence to the above factors can lead to a relatively low cardiovascular mortality rate. . [0003] The pathogenesis of atherosclerosis is inseparable from the inflammatory response affecting the arter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P3/04A61P9/10A61K31/366
CPCA61K31/366A61K31/4375A61P3/04A61P9/10A61K2300/00
Inventor 客蕊班纪芳王卓溪
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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