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Preparation method and application of temperature-sensitive composite hydrogel preparation for endometrial repair

An endometrial repair and composite hydrogel technology, which is applied in the preparation methods of peptides, chemical instruments and methods, and medical preparations containing active ingredients, etc., can solve the problem of incomplete endometrial regeneration and endometrial scar repair. , stem cell reduction and other issues, to enhance the effect of endometrial repair, shorten the operation time, and promote the effect of endometrial regeneration

Pending Publication Date: 2022-06-17
康膝生物医疗(深圳)有限公司
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Problems solved by technology

Injury to the endometrium will lead to the reduction of basal layer stem cells and impaired function, and the endometrium cannot be completely regenerated, leading to scar repair of the endometrium, and the occurrence of intrauterine adhesions over time

Method used

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  • Preparation method and application of temperature-sensitive composite hydrogel preparation for endometrial repair
  • Preparation method and application of temperature-sensitive composite hydrogel preparation for endometrial repair
  • Preparation method and application of temperature-sensitive composite hydrogel preparation for endometrial repair

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Embodiment Construction

[0031] In order to more clearly illustrate the purpose, technical solutions and advantages of the embodiments of the present invention, the present invention will be further described below with reference to the embodiments, and a clear and complete description will be given. Obviously, the described embodiments are part of the embodiments of the present invention, not all examples. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present invention.

[0032] In the present invention, as figure 1 Shown in, a kind of preparation method of temperature-sensitive composite hydrogel preparation for endometrial repair, comprising the following steps:

[0033] S1, prepare a collagen solution and store it at 0-10°C for later use. First, collect collagen-containing tissues from the animal body, which can be pigskin, bovine tendon, etc. Preliminary collag...

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Abstract

The invention relates to a preparation method and application of a temperature-sensitive composite hydrogel preparation for endometrial repair, and the preparation method comprises the following steps: S1, preparing a collagen solution, and storing the collagen solution under a low-temperature condition for later use; s2, preparing an autologous PRP; s3, culturing and amplifying the mesenchymal stem cells; s4, mixing the PRP and the mesenchymal stem cells to prepare a PRP and mesenchymal stem cell suspension, and storing the PRP and mesenchymal stem cell suspension under a low-temperature condition for later use; and S5, at low temperature, mixing the collagen solution with the PRP and mesenchymal stem cell suspension to prepare the temperature-sensitive collagen composite hydrogel preparation, and storing the temperature-sensitive collagen composite hydrogel preparation at low temperature. The preparation provided by the invention can effectively promote the repair of endometrium, shorten the repair time of the endometrium, improve the repair effect and reduce the formation of scar tissues, has the characteristic of thermosensitivity, and improves the convenience of operation.

Description

technical field [0001] The invention relates to a therapeutic agent for endometrial, in particular to a preparation method and application of a thermosensitive composite hydrogel preparation for endometrial repair. Background technique [0002] Endometrial injury is a very common tissue lesion in obstetrics and gynecology, which is generally caused by surgical injury or inflammation, such as curettage, abortion, and endometrial inflammation. Endometrial injury is common in obstetrics and gynecology diseases such as intrauterine adhesions and thin uterus. Endometrial damage can lead to secondary amenorrhea, infertility, habitual abortion, etc. According to literature reports, the incidence of intrauterine adhesions caused by induced abortion and curettage is as high as 25%-30%. And the probability of postoperative re-adhesion recurrence is very high. At present, the standard treatment for intrauterine adhesions at home and abroad is hysteroscopic adhesion dissection combin...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K9/06A61P15/00C07K14/78C07K1/36C07K1/34C07K1/30C07K1/14A61K35/19A61K35/16A61K35/28
CPCA61K38/39A61K35/19A61K35/16A61K35/28A61K9/06A61K9/0019A61K9/0034A61P15/00C07K14/78A61K2300/00
Inventor 王琳邹杰李鉴墨严炎刘星
Owner 康膝生物医疗(深圳)有限公司
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