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Drug delivery system and preparation method and application thereof

A delivery system and drug technology, applied in the field of biomedicine, to achieve the effect of improving diagnostic accuracy, enhancing therapeutic effect, and significant cytotoxicity

Pending Publication Date: 2022-08-05
SURGSCI SHENZHEN MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But at present, the selection of magnetic particles and fluorescent particles needs to be further optimized

Method used

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  • Drug delivery system and preparation method and application thereof
  • Drug delivery system and preparation method and application thereof
  • Drug delivery system and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] The present embodiment provides a CFO, and the preparation method of the CFO comprises the following steps:

[0112] Convert Co(acac) 2 (1mmol) and Fe(acac) 3 (2mmol) was added to a solution containing 6mmol of oleic acid, 10mmol of 1,2-tetradecanediol, 6mmol of oleylamine and 20mL of phenylene ether under N 2 under magnetic stirring. The resulting mixture was then heated to 200 °C for 1.5 h and refluxed at 280 °C for 1 h. After removing the heat source and cooling, the black mixture was washed with acetone and chloroform solvent to give CFO.

Embodiment 2

[0114] This embodiment provides a CFO@SiO 2 NPs, the CFO@SiO 2 The preparation method of NPs includes the following steps:

[0115] 4 mL of the CFO prepared in Example 1 was redispersed into a mixed solution containing 10 mL of deionized water and 40 mL of absolute ethanol. After ultrasonic stirring for 1 h, 1 mL of NH was added 3 ·H 2 O. Then 2 mL of TEOS (tetraethyl orthosilicate) was added, and the reaction was continued for 10 h to obtain CFO@SiO 2 NPs.

Embodiment 3

[0117] This embodiment provides an NH 2 -CFO@SiO 2 NPs, the NH 2 -CFO@SiO 2 The preparation method of NPs includes the following steps:

[0118] The CFO@SiO prepared in Example 2 2 The NPs (brown mixture) were redispersed in 6 mL of absolute ethanol, and 4 mL of the suspension was taken and dispersed in a mixed solution containing 10 mL of deionized water and 40 mL of absolute ethanol. Then, a solution containing 3-aminopropyltriethoxysilane (APTES) (0.75 mL) dissolved in ethanol (10 mL) was added dropwise to the mixture, followed by gentle stirring for 8 h. After several washes, NH was obtained 2 -CFO@SiO 2 NPs, spare.

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Abstract

The invention provides a drug delivery system and a preparation method and application thereof, the drug delivery system takes magnetic nanoparticles as a core layer and takes graphene quantum dot modified silicon dioxide as a shell layer, and graphene quantum dots load adriamycin. The drug delivery system provided by the invention can be used for monitoring drug delivery by detecting FRET signals; the GQDs serve as a drug carrier and a donor at the same time in the FRET model, and the DOX serves as an anti-cancer drug and a receptor in the FRET model; effective drug loading and controlled release are carried out through an FRET model. The drug delivery system provided by the invention not only can be used as a biomarker for tracking and targeting tumors, but also can realize monitoring and delivery of drugs, so that the diagnosis accuracy is improved. The drug delivery system provided by the invention not only can be used for monitoring drug delivery and fluorescence / MRI bimodal cell imaging, but also can be used for simultaneously carrying out cancer diagnosis and treatment.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a drug delivery system and a preparation method and application thereof. Background technique [0002] Advances in nanotechnology in recent years have driven its growing demand in the biomedical field, thanks to the contribution of multifunctional nanoplatforms to nanoscale cancer diagnosis and therapy. The multifunctional nanoplatform is a system that integrates medical targeting, bioimaging, diagnosis and treatment, and holds great promise for future cancer diagnosis and treatment. Currently, multifunctional nanoplatforms are still required to reduce artifacts and significantly improve diagnostic accuracy, reduce harmful non-specific side effects, and aim to overcome limitations associated with conventional anticancer drugs, such as rapid clearance, insolubility in aqueous solutions, and lack of selectivity Wait. [0003] Currently, fluorescence imaging, as one of the m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/54A61K47/52A61K31/704A61K49/00A61K49/08A61K49/10A61K49/18A61K41/00G01N21/64A61P35/00
CPCA61K31/704A61K47/52A61K47/6929A61K47/545A61K41/00A61K9/0009A61P35/00A61K49/0067A61K49/0093A61K49/08A61K49/1824A61K49/10A61K49/0052A61K49/005G01N21/6456
Inventor 滕云冯耿超
Owner SURGSCI SHENZHEN MEDICAL TECH CO LTD
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