Application of eight-treasure pill to preparation of medicine for delaying occurrence and development of colitis-related colon cancer

A technology of Babaodan and colitis, applied in the direction of drug combination, non-living material medical raw materials, medical preparations containing active ingredients, etc., can solve the problem of colon cancer without Babaodan, colitis without Babaodan, etc. question

Pending Publication Date: 2022-08-09
XIAMEN TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is no report that Babaodan is used for colitis, nor is there any report that Babaodan delays the occurrence and development of colitis-associated colon cancer

Method used

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  • Application of eight-treasure pill to preparation of medicine for delaying occurrence and development of colitis-related colon cancer
  • Application of eight-treasure pill to preparation of medicine for delaying occurrence and development of colitis-related colon cancer
  • Application of eight-treasure pill to preparation of medicine for delaying occurrence and development of colitis-related colon cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] Experimental drug and preparation method

[0024] Babaodan Capsule Properties: Capsule contents are yellowish-brown or gray-tan. Supply unit: Xiamen Traditional Chinese Medicine Co., Ltd. Storage method: Store in a cool, dry, room temperature.

[0025] Preparation method of drug for intragastric administration: Weigh the contents of the capsule, add an appropriate amount of MiliQ water to dissolve to the desired concentration (40 mg / mL), store at 4°C after 30 minutes of ice bath ultrasound, and use within 2 hours.

[0026] 1. Research methods

[0027] 1.1 Modeling (CAC model building)

[0028] Thirty-six Balb / C mice were randomly divided into two groups according to body weight: model group (18 mice) and control group (18 mice), model group was injected with azoxymethane (AOM) (12.5mg / kg), one week later, drinking water containing 2.5% dextran sodium sulfate (DSS) was given for 6 days, and then switched to normal drinking water for 2 weeks (this is one cycle), and re...

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Abstract

The invention relates to an application of Babaodan in preparation of a medicine for delaying occurrence and development of colitis-related colon cancer. Experimental results show that the eight-treasure pill can effectively slow down occurrence and development of azomethane oxide/dextran sodium sulfate induced colitis-related colon cancer. Meanwhile, HE staining results of the liver and the spleen show that compared with a blank control group, obvious histopathologic changes cannot be caused to the liver and the spleen after the mouse takes the eight-treasure pill for a long time, and the eight-treasure pill does not have obvious toxicity to the mouse after the mouse takes the eight-treasure pill for a long time.

Description

technical field [0001] The invention belongs to the technical field of Babaodan application, and more particularly relates to the use of Babaodan for preparing a medicine for delaying the occurrence and development of colitis-related colon cancer. Background technique [0002] Babaodan is derived from ancient Chinese medicine recipes and has the functions of clearing dampness and heat, promoting blood circulation and detoxification, removing yellowness and relieving pain. It is suitable for fever, jaundice, yellow urine, nausea and vomiting, anorexia, rib pain, abdominal distention, yellow and greasy tongue coating or thick and dry white coating caused by damp-heat accumulation, or urethral burning and stinging pain, lower abdominal distension and pain caused by damp-heat betting. Infectious viral infection, acute cholecystitis, acute urinary tract infection, etc. [0003] Modern pharmacological studies have shown that Babaodan has anti-inflammatory, antipyretic, analgesic,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/618A61P35/00A61K31/045A61K33/28A61K33/30A61K35/02A61K35/10A61K35/36A61K35/413
CPCA61K35/618A61K35/413A61K35/36A61K35/10A61K35/02A61K33/28A61K31/045A61K33/30A61P35/00A61K2300/00Y02A50/30
Inventor 关斌陈晓琳陈西翌郑珊珊彭军林久茂詹志学赖志成许玉珍施少斌肖惠琳
Owner XIAMEN TRADITIONAL CHINESE MEDICINE
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