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Application of general flavone to regulation of adjuvant arthritis rat intestinal flora

A technology of adjuvant arthritis and intestinal flora, applied in anti-inflammatory agents, non-central analgesics, medical raw materials derived from ferns/filamentous plants, etc., to prevent or treat adjuvant arthritis Effect

Active Publication Date: 2022-08-09
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no report on the relationship between the vitamin C level and the "bacteria-gut-joint axis" in rats with adjuvant arthritis under the action of drugs

Method used

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  • Application of general flavone to regulation of adjuvant arthritis rat intestinal flora
  • Application of general flavone to regulation of adjuvant arthritis rat intestinal flora
  • Application of general flavone to regulation of adjuvant arthritis rat intestinal flora

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] The technical solutions in the embodiments of the present invention will be described clearly and completely below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0028] The following experiments were used to study the relationship between total flavonoids to regulate the intestinal flora, inflammatory cytokines and vitamin C content in rat serum in adjuvant arthritis rats.

[0029] 1 Instruments and materials

[0030] 1.1 Instruments

[0031]

[0032] 1.2 Reagents and consumables

[0033]

[0034]

[0035] 2 methods

[0036] 2.1 Determination of serum vitamin C content in rats

[0037] 2.1.1 Preparation of the test solution

[0038] Modeling: 36 SD male rats were p...

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PUM

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Abstract

The invention discloses an application of general flavone in regulating intestinal flora of adjuvant arthritis rats. At present, under the action of drugs, the relationship between the level of vitamin C in a rat with adjuvant arthritis and'bacterium-intestine-joint axis' is not reported yet. The total flavonoids achieve the effect of preventing or treating adjuvant arthritis by reducing the content of inflammatory cytokines in rat serum, increasing the content of VC in the rat serum, increasing the abundance of phylum firmicum and corynebacterium albicum in the rat intestinal tract and reducing the abundance of phylum proteiniporum and Ralstonia in the rat intestinal tract.

Description

technical field [0001] The invention relates to the application of total flavonoids to regulate intestinal flora of adjuvant arthritis rats. Background technique [0002] Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that damages the synovium, cartilage and bone. The rat adjuvant arthritis model has many similar characteristics to human RA in terms of clinical manifestations, pathological changes, immunological changes and pathological mechanisms. [0003] At present, there is no report on the relationship between vitamin C levels and the "bacteria-gut-joint axis" in adjuvant arthritis rats under the action of drugs. SUMMARY OF THE INVENTION [0004] Aiming at the problems existing in the prior art, the present invention provides an application of total flavonoids for regulating intestinal flora in adjuvant arthritis rats. [0005] In order to solve the above problems, the present invention adopts the following technical scheme: [0006] Applic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/12A61P19/02A61P29/00
CPCA61K36/12A61P19/02A61P29/00Y02A50/30
Inventor 王桂艳王丽红赵稷任恒鑫王宇亮陈洁琳孟卓异
Owner JIAMUSI UNIVERSITY
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