Process for synthesis of medical biodegradable material in presence of bionic organic guanidine salt catalyst
A technology of biodegradable materials and process methods, applied in the preparation of organic compounds, organic compound/hydride/coordination complex catalysts, organic chemistry, etc., can solve problems such as removal and unsafe hidden dangers
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example 1
[0025] Preparation of guanidinium salt catalyst:
[0026] At room temperature, add di-n-butylamine with a molar ratio (triphosgene: di-n-butylamine) of 1:4, 100 ml of anhydrous tetrahydrofuran into a three-necked flask at room temperature, and start to drop 25 ml of anhydrous tetrahydrofuran solution in which about 1 g of triphosgene is dissolved under stirring. At the beginning, the dropping speed should be slow, and white precipitate will be formed immediately, accompanied by a large amount of white mist. After about half an hour, the solution is added dropwise, and there is a light yellow oil in the upper layer, and the stirring is continued for 6 hours.
[0027] The white solid was removed by suction filtration to obtain large flaky crystals, which were dried in a desiccator and recovered for reuse. The filtrate was distilled to remove the solvent tetrahydrofuran under normal pressure to obtain an oily liquid with a white precipitate, which was washed with 2M hydrochloric ...
example 2
[0030] Synthesis of biodegradable polylactic acid:
[0031] According to the reaction conditions of 1 / 200 (proportioning) 120°C and 72 hours, the specific steps are as follows:
[0032] Wash and dry the sealed tube, add about 1 gram of lactide, add an appropriate amount of toluene solution of guanidinium salt and potassium acetate toluene solution according to the required catalyst concentration, cut off the funnel at the top of the sealed tube, and connect the sealed tube to into the vacuum system. Vacuumize, then replace with nitrogen three times, then vacuumize, seal with an alcohol blowtorch, and place the sealed tube vertically in an oil bath with adjusted temperature. When the reaction is over, the sealed tube is taken out, cooled and crushed to obtain the PLA product. The obtained PLA was dissolved in an appropriate amount of acetone, poured into a large amount of deionized water, and the water phase was filtered off. Finally, the PLA was placed in a vacuum drying ove...
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