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Platinum complex having anticancer activity

A technology of platinum complexes, anticancer activity, applied in the field of new platinum complexes, can solve the problems of narrow anticancer spectrum, limited wide application, hair loss, etc.

Inactive Publication Date: 2006-07-12
KUNMING INST OF PRECIOUS METALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this type of drug also has many inherent disadvantages: high toxicity and side effects, nausea, vomiting, hair loss, bone marrow suppression, etc., cross-resistance between each other and narrow anti-cancer spectrum, etc.
These disadvantages limit their wider application

Method used

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  • Platinum complex having anticancer activity

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Embodiment Construction

[0015] Preparation of the platinum complex of the present invention:

[0016] Reagents used: commercially available Pt(NH 3 ) 2 I 2 , commercially available analytically pure AgNO 3 , commercially available analytically pure salicylic acid, commercially available analytically pure NaOH.

[0017] making process:

[0018] Weigh 5 g of Pt(NH 3 ) 2 I 2 Dissolve in 50mL water, add 20mL containing 3.4g AgNO under stirring condition 3 The aqueous solution was reacted for 3 hours, the AgI precipitate was filtered, and the mother liquor was poured into a clean beaker.

[0019] By Pt(NH 3 ) 2 I 2 Measure, weigh an excess of about 10% salicylic acid, add it to the above mother liquor, adjust the pH value of the reaction solution to between 7 and 9 with 20% NaOH solution, react for 1 hour to produce white precipitate, continue to react for 2 hours , filtered the white precipitate, washed three times with water and ethanol respectively, dried and dried at 70° C. to obtain 2.1 g...

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Abstract

The present invention is salicylic acid diamino-platinum (II), with molecular expression of Pt(NH3)2(C7H4O3) and molecular weight 365. The compound has excellent antitumor activity.

Description

technical field [0001] The present invention relates to a novel platinum complex which has antitumor activity. Background technique [0002] In 1969, American scientist Rosenberg discovered that cis-dichlorodiammine platinum (II) (referred to as cisplatin, English abbreviation DDP, English chemical name cisplatin) has anticancer activity. Since then, the research on platinum group metal anticancer drugs has made great progress both in theory and compound synthesis, and it is still a hot research field today. For decades, scientists from various countries have successively synthesized thousands of platinum compounds and evaluated their antitumor activity. Among them, more than 30 compounds have entered the clinical trial stage, but only a few have been finally approved for clinical use. Cisplatin, carboplatin, and oxaliplatin, which have been clinically used, are widely used around the world, while nedaplatin, roplatin, sulplatin, and cyclothioplatin are only approved for u...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F15/00A61P35/00C07H15/00
Inventor 普绍平李学杰刘祝东高文桂刘伟平
Owner KUNMING INST OF PRECIOUS METALS