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Liver specificity CT contrast medium and its preparation method

A specific, contrast agent technology, applied in the field of liver-specific contrast agent and its preparation, can solve the problems of unstable preparation, encapsulation efficiency, low drug loading, etc., and achieve the effect of improving sensitivity and specificity

Inactive Publication Date: 2006-11-08
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the research on macromolecular or granular CT liver-specific contrast agents is mostly focused on the use of liposomes as carriers to encapsulate conventional CT contrast agents, which are taken up by the liver after intravenous injection to achieve the purpose of liver-specific enhancement, but liposomes Common shortcomings such as encapsulation efficiency, low drug loading, and unstable formulations

Method used

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  • Liver specificity CT contrast medium and its preparation method
  • Liver specificity CT contrast medium and its preparation method

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Embodiment 1

[0024] Embodiment 1: triiodophenol ethyl cellulose microspheres and preparation thereof

[0025] 1. Triiodophenol and ethyl cellulose of 1:2 (W / W) ratio are dissolved in an appropriate amount of dichloromethane;

[0026] II. Add the solution to a 3% PVA aqueous solution, emulsify for 3 minutes at 12000 rpm, add an appropriate amount of water, and stir at a low speed for 20 hours to volatilize the dichloromethane;

[0027] III. Leave for 1-3 days to allow the impurities to settle, and some larger particles also settle at the bottom, discard the sediment;

[0028] IV. Centrifuge the milky white suspension at 12,000 rpm at high speed to obtain white particles, wash with water three times;

[0029] V. Vacuum drying at 40° C. to obtain white powder of triiodophenol ethyl cellulose microspheres.

[0030] VI. Particle determination: eg figure 1 , figure 2 As shown, the particle size distribution is 1.8-6.1 microns, the average is 3.62 microns, the iodine content is 33.4% (W / W), ...

Embodiment 2

[0031] Embodiment 2: 2,4,6-triiodobenzoic acid ethyl cellulose microspheres and its preparation

[0032] Triiodophenol in Example 1 was replaced by 2,4,6-triiodobenzoic acid.

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Abstract

The invention relates to the technical field of medical detection reagents. CT liver-specific contrast agent refers to the use of phagocytosis of kupffer cells in the reticuloendothelial system of the liver to specifically accumulate the contrast agent in the liver, which improves the sensitivity and specificity of CT diagnosis. At present, the research on macromolecular or granular CT liver-specific contrast agents is mostly focused on encapsulating conventional CT contrast agents with liposomes, which generally have disadvantages such as low encapsulation efficiency, low drug loading, and unstable preparations. The invention provides a liver-specific CT contrast agent and a preparation method thereof. It adopts ethyl cellulose as a carrier, wraps derivatives of triiodoisophthalic acid, and obtains iodine-containing ethyl cellulose microspheres.

Description

technical field [0001] The invention relates to the technical field of medical detection reagents, in particular to a liver-specific contrast agent for CT (computed tomography) contrast enhancement and a preparation method thereof. Background technique [0002] CT (X-ray computed tomography) is a commonly used clinical diagnostic method. CT liver-specific contrast agent refers to the phagocytosis of kupffer cells in the reticuloendothelial system of the liver. After kupffer cells phagocytose macromolecular or granular contrast agents, the The contrast agent is cleared from the blood and specifically accumulates in the normal liver parenchyma, increasing the CT value of the liver. When liver lesions occur, especially when malignant tumors occur, the tumor tissue lacks normal Kupffers cells and cannot absorb macromolecular contrast agents. Contrast improves the sensitivity and specificity of CT diagnosis. [0003] At present, the research on macromolecular or granular CT liv...

Claims

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Application Information

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IPC IPC(8): A61K49/00
Inventor 姜庆军刘瑞丽刘士远李文新李文涛袁正
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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