Gum of ambroxol hydrochloride and preparation thereof

A technology of ambroxol hydrochloride and soft capsule, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problem that injections and large infusions can only be used in hospitals and are not suitable for children and the elderly. , aerosol packaging is expensive and other problems, to achieve the effect of not easy to break, accurate dose, fast onset

Inactive Publication Date: 2007-04-25
肖春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the tablet is easy to carry, its water solubility is poor, so it is not suitable for children and the elderly; the solution is inconvenient to carry, and the dosage when taking it is not accurate; It is inconvenient to carry the medicine, and the aerosol packaging is expensive; injections and large infusions can only be taken in hospitals, and the cost is relatively high, and it is extremely inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A soft ambroxol hydrochloride chewable gum is characterized in that it is formulated into 1000 grains by the raw materials of the following weight ratio:

[0040] Ambroxol Hydrochloride 10g

[0041] Glycerin 40g

[0042] Polyethylene glycol 300ml

[0043] water 20ml

[0044] Peppermint Oil 0.2ml

[0045] Aspartame 0.1g

[0046] Edible gelatin, glycerin, and water required for making glue.

[0047] The preparation method of described ambroxol hydrochloride chewable soft capsules comprises the following processing steps:

[0048] A, pharmaceutical pills: Dissolve ambroxol hydrochloride in glycerin, polyethylene glycol and water for injection according to the above weight ratio, heat to clarify the solution, add surfactant to absorb pyrogen, filter, then add peppermint to the filtrate Oil and aspartame, and finally check the content of ambroxol hydrochloride, and adjust the pH value of the solution to 6-9 with 0.1mol / l NaOH, and press the pellets after passing the te...

Embodiment 2

[0054] A chewable soft capsule of ambroxol hydrochloride is characterized in that it is formulated into 2000 grains by the raw materials of following weight ratio:

[0055] Ambroxol Hydrochloride 40g

[0056] Glycerin 80g

[0057] Polyethylene glycol 500ml

[0058] water 50ml

[0059] Peppermint Oil 1.0ml

[0060] Aspartame 1.0g

[0061] Edible gelatin, glycerin, and water required for making glue.

[0062] The preparation method of described ambroxol hydrochloride chewable soft capsules comprises the following processing steps:

[0063] A, pharmaceutical pills: Dissolve ambroxol hydrochloride in glycerin, polyethylene glycol and water for injection according to the above weight ratio, heat to clarify the solution, add surfactant to absorb pyrogen, filter, then add peppermint to the filtrate Oil and aspartame, and finally check the content of ambroxol hydrochloride, and adjust the pH value of the solution to 6-9 with 0.1mol / l NaOH, and press the pellets after passing the t...

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PUM

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Abstract

A chewing softgel of ambroxol hydrochloride is prepared from ambroxol hydrochloride, glycerine, polyethanediol, water, mint oil, and sweetening agent through proportional mixing, fusing, pilling and baking.

Description

technical field [0001] The present invention relates to a kind of ambroxol hydrochloride pharmaceutical preparation and its preparation method which has expectorant effect and can significantly promote the synthesis and secretion of alveolar surface active substance, especially relates to the chewable soft capsule preparation of this kind of medicine and its Preparation. Background technique [0002] Ambroxol hydrochloride, also known as Mushu phlegm, is currently the most effective expectorant in clinical practice. It was launched in Germany in the early 1980s, and later in Japan and many European countries. Ambroxol hydrochloride is the active metabolite of bromhexine in the body. It is a new mucolytic drug that can promote the secretion of pulmonary surfactant and airway fluid, and has a significant effect on the synthesis and secretion of alveolar surfactant. It can stimulate bronchial mucus glands to secrete mucus that is easier to flow, dilute sputum, reduce viscosity...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K31/137A61K9/20A61P11/10
Inventor肖春
Owner肖春