Thymosin composition injection and its prepn

A technique for thymosin and injections, which is applied in the field of thymosin composition injections and its preparation, can solve the problems of clinical allergic reactions and side effects, imperfect dosage forms and components, and unreasonable production processes, and achieve clinical allergic reactions and side effects. The effect of perfect components and reasonable production process

Inactive Publication Date: 2003-02-26
湖南康源制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The existing thymosin drugs have low purity, poor stability, insufficient curative effect, and large clinical allergic reactions and side effects due to imperfect dosage forms and components, and unreasonable production processes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0038] Specific embodiments Example 1 Small-volume injection

[0039] l. The components are:

[0040] Thymosin 20000mg

[0041] Reduced Glutathione 20000mg

[0042] Sodium chloride (for injection) 45g

[0043] Add water for injection to 5000ml

[0044] Sodium sulfite concentration is 0.05mol

[0045] The above medicines are divided into 1000 pieces

[0046] 2. Production process steps of small volume injection

[0047] (1) Add the above-mentioned components except reduced glutathione and sodium chloride into water for injection to make 4500ml;

[0048] (2) Passing sterile and dust-free compressed air containing ozone concentration of 12PPm into the above-mentioned liquid medicine, stirred by carrier gas flow, and sterilized for 30 minutes;

[0049] (3) Add superior grade pure calcium chloride crystal, make its concentration be 0.05mol;

[0050] (4) The medicinal liquid is filtered through two-stage membranes of 0.45 μm and 0.22 μm;

[0051] (5) Set t...

Embodiment 2

[0053] Embodiment two freeze-dried powder injection

[0054] 1. The components are:

[0055] Thymosin 20000mg

[0056] Reduced Glutathione 20000mg

[0057] Sodium chloride (for injection) 18g

[0058] Add water for injection to 2000ml

[0059] Sodium sulfite concentration is 0.05mol

[0060] The above medicines are divided into 1000 pieces

[0061] 2. Production process steps

[0062] (1) adding the above-mentioned components except reduced glutathione and sodium chloride to water for injection;

[0063] (2) Passing sterile and dust-free compressed air containing ozone concentration of 12PPm into the above-mentioned liquid medicine, stirred by carrier gas flow, and sterilized for 30 minutes;

[0064] (3) Add superior grade pure calcium chloride crystal, make its concentration be 0.05mol;

[0065] (4) The medicinal liquid is filtered through two-stage membranes of 0.45 μm and 0.22 μm;

[0066] (5) Set the volume to 2000ml with sterile water for injection, add 15% sodiu...

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Abstract

The present invention is one kind of thymosin composition injection and its preparation. It consists of thymosin and reductive glutathione in the weight ratio of 1-10 to 2-120 as well as pharmaceutically acceptable supplementary material. It has perfect dosage form, reasonable production process, high purity, high stability, high curative effect, and less allergic reaction and side effect.

Description

technical field [0001] The invention relates to a thymosin peptide drug, in particular to a thymosin peptide composition injection and a preparation method thereof. technical background [0002] The existing thymosin drugs have low purity, poor stability, insufficient curative effect, and large clinical allergic reactions and side effects due to imperfect dosage forms and components, and unreasonable production processes. Contents of the invention [0003] The object of the present invention is to overcome the above-mentioned shortcoming of prior art, provide a kind of stability, curative effect good, the thymosin composition injection of clinical allergic reaction and side effect; The object of the present invention also is to provide its preparation method of this invention medicine. [0004] In order to achieve the above object, the thymosin composition injection of the present invention is made of the following raw materials in weight ratio: [0005] Thymosin 1-10 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K38/32
Inventor 蔡海德
Owner 湖南康源制药有限公司
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