Genetic vaccine that mimics natural viral infection and induces long-lasting immunity to pathogens

A virus antigen, virus technology, applied in the direction of virus/phage, virus antigen component, virus, etc., can solve the problem of not inducing cell response and so on

Inactive Publication Date: 2003-10-01
GENPHAR INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

What's more, current vaccines do not induce potent cellular responses against infected cells, the source of newly released virions

Method used

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  • Genetic vaccine that mimics natural viral infection and induces long-lasting immunity to pathogens
  • Genetic vaccine that mimics natural viral infection and induces long-lasting immunity to pathogens
  • Genetic vaccine that mimics natural viral infection and induces long-lasting immunity to pathogens

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Embodiment Construction

[0083] The invention provides a genetic vaccine, a pharmaceutical composition containing the vaccine, and a method for immunizing a host against various pathogenic viruses, bacteria and parasite infections. The genetic vaccine is a recombinant benign virus with replication defects, and will not cause malignant tumors in the host to be immunized. Vaccination using the genetic vaccine of the present invention mimics natural viral infection because: compared to the traditional "outside-out" mechanism of vaccination using denatured proteins or viruses as vaccines, Antigens expressed by cells infected with this genetic vaccine are presented to the host's immune system in a native conformation and by an "inside-out" mechanism. In addition, cells infected with this genetic vaccine also released high levels of cytokines, which mimicked the cells' natural response to the stress induced by viral infection without causing pathogenic effects on the cells. Misled by this "pathogenic viral...

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Abstract

The present invention provides genetic vaccines and methods for enhancing the immunity of a host, such as a human, against one or more pathogens. In one embodiment, a recombinant benign virus is provided as a genetic vaccine. The recombinant virus contains: an antigenic sequence heterologous to the recombinant virus, which encodes a viral antigen from the pathogenic virus. When the host is infected by the recombinant virus, the expression of the viral antigen causes the viral antigen to be directed to and in the host. an immune response in cells expressing the viral antigen; and an immunostimulator sequence heterologous to said recombinant virus, said immunostimulator sequence encoding an immune stimulator whose expression in the host increases the viral The immunogenicity of the antigen. The recombinant virus is replication incompetent and does not cause malignancies in the host that are naturally associated with the pathogenic virus. The genetic vaccine can be used to confer immunity to the host against many pathogens such as HIV, Ebola virus, hepatitis B virus, hepatitis C virus, influenza virus, pathogenic bacteria and parasites.

Description

field of invention [0001] The present invention relates to vaccines for stimulating immune responses in humans and other hosts, and, more particularly, to recombinant viruses expressing heterologous antigens of pathogenic viruses such as Ebola, HIV, hepatitis, and influenza. Background of the invention [0002] Current vaccine development techniques are largely based on the idea of ​​using denatured viruses or purified viral proteins made from bacteria. These types of vaccines are only effective against a limited number of infectious agents and have a limited rate of protection. [0003] For viruses that contain membrane (envelope) glycoproteins (GPs), including Ebola virus and HIV virus, it usually does not work satisfactorily with denatured virus or purified viral proteins. There may be several reasons for this. First, the GPs of these viruses are sensitive to the denaturation process, thus the epitopes of these proteins are changed by the denaturation process. Second, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/09A61K39/00A61K39/02A61K39/12A61K39/21A61K39/235A61K39/245A61K39/29A61P31/04A61P31/12A61P33/00C07K14/08C07K14/16C12N7/00C12N15/33C12N15/83
CPCA61K39/12A61K39/21A61K39/292A61K2039/5256A61K2039/53A61K2039/55522A61K2039/57C07K14/005C12N2710/10343C12N2740/16122C12N2740/16322C12N2760/14122A61K2039/545A61K2039/55533C12N2740/16034C12N2760/14134A61P31/04A61P31/12A61P33/00Y02A50/30
Inventor 王丹鹤
Owner GENPHAR INC
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