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Aaalgesic prepared Chinese medicine with non-addiction and its preparing technique method

A non-addictive, process-based technology, applied in the direction of non-central analgesics, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as obvious side effects, blood pressure drop, and intracranial pressure increase, and the effect is obvious , small dose, small side effects

Inactive Publication Date: 2003-10-08
石俊义 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Most of the existing analgesics at home and abroad are mostly western medicine monomer preparations. Due to the high purity, the drug effect is fast and obvious, but the side effects are also obvious, such as morphine, meperidine, anon pain, fentanyl, sedatives, etc. Tongxin, Qiangtongding, Xiaotongding, Methadone, etc. are addictive; while Tetrahydropalmatine, Rotundine, Nefopam, Ketongning, etc. can inhibit breathing, which can cause dizziness, vomiting, and constipation. It can also lower blood pressure and increase intracranial pressure; morphine-based western medicine preparations are effective for many pain patients such as chronic obstructive pulmonary disease, bronchial asthma, cor pulmonale, intracranial injury, liver function decline, biliary colic, etc. All need to be banned or used with caution, and there are many restrictions on taking

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 (tablet production process),

[0019] [Prescription] Yanhusuo 1500g, poppy shell 1000g, appropriate amount of accessories, made into 1000 tablets

[0020] [Preparation method] (1) Corydalis extract: Soak the liquid with 70% ethanol (about 10 times the amount) containing 2% glacial acetic acid, reflux and extract twice, the first time for 3 hours, the second time for 2 hours, and combine the extracts , filtered, ethanol was recovered from the filtrate, concentrated to a clear paste with a relative density of 1.35-1.40 (55°C), and submitted for inspection.

[0021] (2) Poppy shell extraction: Soak the liquid with 60% ethanol (about 15 times the amount), reflux and extract twice, the first time for 3 hours, the second time for 2 hours, combine the extracts, filter, and recover the ethanol from the filtrate, concentrate To the clear ointment with a relative density of 1.35-1.40 (55°C), the dregs were extracted with lime water for 2 hours under reflux; then, ex...

Embodiment 2

[0050] Embodiment 2 (capsule production process),

[0051] [Prescription] Yanhusuo 1500g, poppy shell 1000g, appropriate amount of auxiliary materials, made into 1000 capsules

[0052] [Preparation method] (1) Corydalis extract: Soak the liquid with 70% ethanol (about 10 times the amount) containing 2% glacial acetic acid, reflux and extract twice, the first time for 3 hours, the second time for 2 hours, and combine the extracts , filtered, ethanol was recovered from the filtrate, concentrated to a clear paste with a relative density of 1.35-1.40 (55°C), and submitted for inspection.

[0053] (2) Poppy shell extraction: Soak the liquid with 60% ethanol (about 15 times the amount), reflux and extract twice, the first time for 3 hours, the second time for 2 hours, combine the extracts, filter, and recover the ethanol from the filtrate, concentrate To the clear ointment with a relative density of 1.35-1.40 (55°C), the dregs were extracted with lime water for 2 hours under reflux...

Embodiment 3

[0068] Embodiment 3 (granule production process),

[0069] [Prescription] Yanhusuo 300g, poppy shell 200g, appropriate amount of accessories, made into 1000g

[0070] [Preparation method] (1) Corydalis extract: Soak the liquid with 70% ethanol (about 10 times the amount) containing 2% glacial acetic acid, reflux and extract twice, the first time for 3 hours, the second time for 2 hours, and combine the extracts , filtered, ethanol was recovered from the filtrate, concentrated to a clear paste with a relative density of 1.35-1.40 (55°C), and submitted for inspection.

[0071] (2) Poppy shell extraction: Soak the liquid with 60% ethanol (about 15 times the amount), reflux and extract twice, the first time for 3 hours, the second time for 2 hours, combine the extracts, filter, and recover the ethanol from the filtrate, concentrate To the clear ointment with a relative density of 1.35-1.40 (55°C), the dregs were extracted with lime water for 2 hours under reflux; then, extracted ...

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PUM

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Abstract

An antalgic Chinese patent medicine without addiction contains more than 20 morphinic alkaloids and more than 30 corydalis alkaloids. It is prepared from corydalis tuber and poppy capsule through immersing corydalis tuber in acidic alcohol solution and immersing poppy capsule in alcohol solution to extract their active components.

Description

【Technical field】 [0001] The invention relates to the field of Chinese patent medicines, in particular to the field of pain-relieving Chinese patent medicines and a preparation process thereof. 【Background technique】 [0002] Most of the existing analgesics at home and abroad are mostly western medicine monomer preparations. Due to the high purity, the drug effect is fast and obvious, but the side effects are also obvious, such as morphine, meperidine, anon pain, fentanyl, sedatives, etc. Tongxin, Qiangtongding, Xiaotongding, Methadone, etc. are addictive; while Tetrahydropalmatine, Rotundine, Nefopam, Ketongning, etc. can inhibit breathing, which can cause dizziness, vomiting, and constipation. It can also lower blood pressure and increase intracranial pressure; morphine-based western medicine preparations are effective for many pain patients such as chronic obstructive pulmonary disease, bronchial asthma, cor pulmonale, intracranial injury, liver function decline, biliary ...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61P25/04A61P29/00
Inventor 石俊义
Owner 石俊义
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