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Chinese patent medicine for suppressing pain without habituation and its preparation method

It is a non-addictive, process-based technology that can be used in non-central analgesics, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve problems such as obvious side effects, increased intracranial pressure, and decreased blood pressure, and achieve obvious effects. , small dose, small side effects

Inactive Publication Date: 2003-04-16
石俊义 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Most of the existing analgesics at home and abroad are mostly western medicine monomer preparations. Due to the high purity, the drug effect is fast and obvious, but the side effects are also obvious, such as morphine, meperidine, anon pain, fentanyl, sedatives, etc. Tongxin, Qiangtongding, Xiaotongding, Methadone, etc. are addictive; while Tetrahydropalmatine, Rotundine, Nefopam, Ketongning, etc. can inhibit breathing, which can cause dizziness, vomiting, and constipation. It can also lower blood pressure and increase intracranial pressure; morphine-based western medicine preparations are effective for many pain patients such as chronic obstructive pulmonary disease, bronchial asthma, cor pulmonale, intracranial injury, liver function decline, biliary colic, etc. All need to be banned or used with caution, and there are many restrictions on taking

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Tablet production process: get the original drug of Corydalis Corydalis 1500g, soak the original drug with 70% ethanol (W / W%) solution containing 2% glacial acetic acid of 10 times the amount, reflux extraction twice, the first time for 3 hours, the second time After 2 hours, the combined extracts were filtered, and the filtrate reclaimed ethanol, and concentrated to a relative density of 1.35 to 1.40 (at 55° C.) to obtain Yanhusuoqing ointment; simultaneously get the former medicine 1000 g of poppy shell, and use 60% ethanol (W / W%) solution soaks the former drug, reflux extracts twice, the first time is 3 hours, the second time is 2 hours, the combined extract is filtered, the filtrate reclaims ethanol, and is concentrated to a relative density of 1.35~1.40 (at 55 ℃) to get Morphine-based clear paste; add the same amount of starch to the two types of clear paste, and ventilate and dry at a temperature of 60-80°C until the water content is about 5%, and sieve out the fi...

Embodiment 2

[0021] Injection production process: get Corydalis Corydalis 300g, soak the original drug with 70% ethanol (W / W%) solution containing 2% glacial acetic acid of 10 times the amount, reflux extraction twice, the first time for 3 hours, the second time After 2 hours, combine the extracts and filter, recover the ethanol from the filtrate, and concentrate it to a relative density of 1.35-1.40 (at 55°C) to obtain Corydalis Corydalis Clear Paste, which is dissolved by adding 10 times the amount of acidic water, placed for filtration, and separated. The filtrate is concentrated into a thick paste, then dissolved in 5 times the amount of ethanol, placed and filtered, and the filtrate is taken to recover ethanol to obtain a concentrated thick paste with a relative density of 1.35 to 1.40 (at 55°C); Double the amount of 60% ethanol (W / W%) solution to soak the original drug, reflux extraction twice, the first time for 3 hours, the second time for 2 hours, the combined extracts were filtere...

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PUM

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Abstract

An antalgic Chinese patent medicine without addiction is prpared from corydalis tuber and poppy capsule through immersing in solvent to extract their active components. It contains 20 morphine alkaloids and 10 corydalis alkaloids. Its advantages are broad spectrum, no addiction and no toxic by-effect.

Description

【Technical field】 [0001] The invention relates to the field of Chinese patent medicines, in particular to the field of pain-relieving Chinese patent medicines and a preparation process thereof. 【Background technique】 [0002] Most of the existing analgesics at home and abroad are mostly western medicine monomer preparations. Due to the high purity, the drug effect is fast and obvious, but the side effects are also obvious, such as morphine, meperidine, anon pain, fentanyl, sedatives, etc. Tongxin, Qiangtongding, Xiaotongding, Methadone, etc. are addictive; while Tetrahydropalmatine, Rotundine, Nefopam, Ketongning, etc. can inhibit breathing, which can cause dizziness, vomiting, and constipation. It can also lower blood pressure and increase intracranial pressure; morphine-based western medicine preparations are effective for many pain patients such as chronic obstructive pulmonary disease, bronchial asthma, cor pulmonale, intracranial injury, liver function decline, biliary ...

Claims

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Application Information

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IPC IPC(8): A61P25/04A61P29/00
Inventor 石俊义
Owner 石俊义
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