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Process of extracting total flavone glycoside from mistletoe and medicine composition thereof

A technology of total flavonoid glycosides and mistletoe, applied in the direction of drug combination, sugar derivatives, sugar derivatives, etc.

Inactive Publication Date: 2003-10-15
徐东铭
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional Chinese medicine mistletoe is used as a raw material to prepare a large amount of total flavonoid glycosides of mistletoe (the content reaches more than 50% w / w), and it is used for the prevention and treatment of cardiovascular and cerebrovascular sclerosis or embolism, arrhythmia and hypertension. to report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1: Preparation of total flavonoid glycosides from mistletoe

[0060] Take 1kg of dried mistletoe and add 8kg of water, heat and boil three times, 40 minutes each time. Collect and combine the water extracts of gained, the extract is decolorized with 2% medicinal active carbon, or through ion resin decolorization, filters, and the filtrate is added to the macroporous adsorption resin (example AB-8, Tianjin, China) of treating with acid and alkali in advance Nankai University Chemistry) column, wash the column with deionized water until the eluate has no color, and then elute with 70% ethanol (about 500ml). The eluate was collected, recovered under reduced pressure, dried, and the resulting concentrate was dissolved in 80% ethanol solution, placed, and filtered. The filtrate was concentrated and dried under reduced pressure to obtain total flavonoid glycosides of mistletoe in yellow powder form.

Embodiment 2

[0062] Take 1kg of mistletoe and add 6kg of water, heat and boil three times, 40 minutes each time. Collect and combine the obtained water extracts, concentrate, add ethanol solution until the alcohol concentration is 70%, or extract with 85% ethanol solution, the extract or alcohol solution can be decolorized with 2% medicinal activated carbon, or through ion resin Decolorize, or directly filter without decolorization, recover the ethanol liquid until there is no alcohol liquid smell, add the liquid medicine to the macroporous adsorption resin (example AB-8, Nankai University Chemistry, Tianjin, China) column that has been treated with acid and alkali in advance, and use deionization The column was washed with water until the eluate was colorless, and then eluted with 70% ethanol (about 500ml). The eluate was collected and concentrated under reduced pressure under reflux to obtain total flavonoid glycosides of mistletoe as yellow powder.

Embodiment 3

[0064] Take 100 g of total flavonoid glycosides from mistletoe, dissolve them in 75% ethanol to make a 5% total flavonoid solution, decolorize them with activated carbon, filter, concentrate and dry under reduced pressure, add water for injection to make a 5% aqueous solution, and use a microporous membrane (φ0.20μm) filtered until clear, sterilized, aseptically dispensed into vials, 1ml per bottle, and freeze-dried in a freeze dryer to obtain final product.

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PUM

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Abstract

The technological process of extracting general flavone glycoside from mistletoe herb includes the steps of alcohol or water extraction of mistletoe herb, filtering, macroporous adsorbing resin column purification, alcohol elution to no color, collection of the eluted liquid, recovering alcohol to no alcohol smell, concentration at decompression or normal pressure condition to obtain extraction or dry powder, alcohol dissolving, filtering, removing precipitate to obtain filtrate, decompression recovering alcohol to obtain mistletoe general flavone. The mistletoe general flavone is used as the basic active component of medicine for preventing and treating cardiac and cerebral vascular cirrhosis and embolism, arrhythmia and hypertension, etc.

Description

Technical field: [0001] The invention discloses a method for extracting total flavonoid glycosides from mistletoe and a pharmaceutical composition thereof, specifically a pharmaceutical composition using total mistletoe flavonoid glycosides extracted from mistletoe as the basic active ingredient, and also relates to the mistletoe total flavonoid glycosides The preparation method of the flavonoid glycosides and the application of the new medical application of the total flavonoids of mistletoe belong to the technical field of the extraction method of the effective components of the traditional Chinese medicine and the new medical application thereof. Background technique: [0002] Mistletoe Viscum coloratum (komar.) Nakai. In plant taxonomy, it belongs to the genus Mistletoe of the family Morustaceae. Semi-parasitic evergreen small shrub, the main production area is in the northeast, and it mainly parasitizes on elm, birch, willow, maple, poplar and other trees. In tradition...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/06A61P9/10A61P9/12C07H1/08C07H17/07
Inventor 徐东铭刘平
Owner 徐东铭
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