Production of acetooxdralpeptide
A technology of octreotide acetate and production process, which is applied in the production of bulk chemicals and peptides, and can solve the problems of price restrictions and high prices for patients
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[0005] (1) Take 10g of Boc-Thr(Ac)-Wang resin (1.01mmol / g, 1.01mmol) and put it into a reaction vessel, soak it with 100mlDMF, wash to make the resin fully expand, add 50ml of TFA and 50ml of dichloromethane The mixed solution was reacted at 25°C for half an hour, washed three times with DMF, absolute ethanol, dichloromethane, and DMF respectively, drained, added 8ml of triethylamine and 92ml of dichloromethane mixture, reacted at 25°C for ten minutes, and washed with DMF and dichloromethane were washed three times each, drained, added 23.4g Fmoc-Cys(Trt)-OH, 12.8g TBTU, 6.1g HOBt, dissolved with 80ml of peptide reagent, reacted at 25°C for one hour, respectively with DMF, without Wash with water, ethanol, dichloromethane, and DMF three times each, and drain. (2) If the above-mentioned reagents are positive for amino groups by Karl Fischer’s method, use 40ml of peptide-connecting reagent to make up the connection, and then repeat with DMF, absolute ethanol, dichloromethane, and...
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