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Pharmaceutical composition containing fenofibrate with high efficacy for hyperlipemia, its preparation method and use

A technology of fenofibrate and composition, which is applied in the field of oral preparations containing fenofibrate, can solve the problems of "peak-valley" phenomenon and large fluctuation of blood drug concentration

Inactive Publication Date: 2004-06-16
江苏恩华赛德药业有限责任公司 +1
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Problems solved by technology

[0005] Although the preparation methods disclosed in the two patents cited above have significantly improved the bioavailability of fenofibrate, their immediate release characteristics will lead to large fluctuations in the blood concentration of fenofibrate in patients after administration, which has "Peak and valley" phenomenon, which is undoubtedly unfavorable for patients with chronic cardiovascular disease who need long-term medication

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  • Pharmaceutical composition containing fenofibrate with high efficacy for hyperlipemia, its preparation method and use
  • Pharmaceutical composition containing fenofibrate with high efficacy for hyperlipemia, its preparation method and use
  • Pharmaceutical composition containing fenofibrate with high efficacy for hyperlipemia, its preparation method and use

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Embodiment Construction

[0014] The invention provides a sustained-release fenofibrate composition or preparation, which comprises fenofibrate granules with an average particle diameter of ≤5 μm and inert auxiliary materials.

[0015] According to the present invention, inert excipients mainly include excipients, binders, lubricants, etc., and may also contain any excipients commonly used in the pharmaceutical field. Excipients that can be used in the present invention are exemplified: microcrystalline cellulose, lactose, starch, colloidal silicon dioxide, glycerides, stearic acid, cross-linked polyvinylpyrrolidone, carboxymethyl starch, hydroxypropyl cellulose, Hydroxymethylcellulose, hydroxypropylmethylcellulose, gelatin, etc. A preferred excipient in the present invention is talc in an amount of 30-50% by weight of the composition. The binder was 2% by weight of the composition of HPMC in 75% ethanol.

[0016] According to the present invention, the average particle size of fenofibrate in the pre...

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Abstract

The invention relates to a novel pharmaceutical preparation containing fenofirate (chemical name: 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoicacid-1-methylethylester and process for the preparation, the invention relates to in particular an oral preparation containing fenofirate which can substantially increase the bioavailability of fenofirate and realize slow release for fenofirate.

Description

field of invention [0001] The present invention relates to a new pharmaceutical preparation containing fenofibrate (fenofirate, chemical name: 2-(4-(4-chlorobenzoyl)phenoxy)-2-isopropyl methylpropionate) and its The preparation method, more specifically, the invention relates to an oral preparation containing fenofibrate, which can significantly improve the bioavailability of fenofibrate and release fenofibrate slowly. Background technique [0002] Fenofibrate is a known blood lipid-lowering drug, which can significantly reduce blood cholesterol, triglyceride and increase high-density lipoprotein. It is clinically used for the treatment of hypercholesterolemia and hypertriglyceridemia. It can be used to treat cardiovascular and cerebrovascular diseases such as atherosclerosis and coronary heart disease. The preparation of fenofibrate is mainly common capsule preparation, the unit dose is 100mg / capsule, and the administration method is oral, one capsule each time, three time...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/20A61K9/48A61K31/216A61P3/06
Inventor 汪海祁超包存刚王倩余以兵郭绪义蒋泉福
Owner 江苏恩华赛德药业有限责任公司
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