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Oral preparation of chinese medicine 'kekeping' for treating cold

A technology of oral preparations and buccal tablets, which is applied in the field of Rekeping cold medicine, can solve the problems of injection site pain, inconvenient use, and reduced curative effect, and achieve the effects of stable preparation, convenient use, and reduced pain

Inactive Publication Date: 2004-06-30
郑州市光扬中药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantages are: the drug is inconvenient to use, prone to allergic reactions and myocardial damage, pain at the injection site, easy to harden, and brings great pain to the patient
The preparation failed to utilize the non-volatile components of the two medicinal materials, another active ingredient in Bupleurum bupleuri, saikosaponin, which is considered to be the main active ingredient for antipyretic, analgesic and anti-inflammatory in Bupleurum bupleuri. Due to the limitation of the dosage form, the medicinal materials are wasted and the curative effect is reduced.
Its volatile oil is dispersed in the solution, which is easily changed by light and heat, unstable and inconvenient to store

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] Example 1: Take 275 grams each of Bupleurum vulgare and Schistosoma vulgare, add water and distill for 2 hours, and volatile oil is included with -cyclodextrin to obtain the volatile oil inclusion compound of the two medicines of Bupleurum vulgare and Schizochondriac Gram contains 0.1ml of cyclohexanol, limonene, octyl aldehyde, -pinene, etc., and the water is filtered for later use; the medicine residue is added with water and decocted for 0.5 hours, filtered, and the two filtrates are combined and concentrated under reduced pressure to a relative density of 1.05 (80 ℃), add ethanol until the alcohol content reaches 60%, place it, filter, and recover the ethanol to dryness under reduced pressure to obtain the non-volatile active ingredient extracts of Bupleurum and Goose. Saponin 0.05g.

[0125] Take the same amount of polyethylene glycol 6000 as the above-mentioned Bupleurum and Gooseberry extract as the matrix, heat it to 80°C to melt it, add the above-mentioned volati...

Embodiment 2

[0126] Example 2: Take 275 grams each of Bupleurum edulis and Rhizoma edulis and distilled for 4 hours. The volatile oil was included with -cyclodextrin to obtain the inclusion compound of volatile oil of the two herbs of Bupleurum spp. Gram contains 0.12ml of cyclohexanol, limonene, octaldehyde, -pinene, etc., and the water is filtered for later use; the dregs are added with water and decocted for 1 hour, filtered, and the two filtrates are combined and concentrated under reduced pressure to a relative density of 1.1 (80 ℃), add ethanol until the alcohol content reaches 70%, place, filter, and recover the ethanol to dryness under reduced pressure to obtain the non-volatile active ingredient extract of Bupleurum and Goose. Saponin 0.08g.

[0127] Take the polyethylene glycol 4000 of 1.5 times the amount of the above Bupleurum and Goose grass extract as the matrix, heat it to 90°C to melt, add the above volatile oil extract and non-volatile component extract under the heat preser...

Embodiment 3

[0128] Example 3: Take 275 grams each of Bupleurum edulis and Herbalism, add water and distill for 5 hours, and the volatile oil was included with -cyclodextrin to obtain the volatile oil inclusion compound of the two medicines of Bupleurum edulis and Acanthus Gram contains 0.15ml of cyclohexanol, limonene, octaldehyde, -pinene, etc., filter the water for use; add water and decoct the residue for 2 hours, filter, combine the two filtrates, and concentrate under reduced pressure to a relative density of 1.2 (80 ℃), add ethanol until the alcohol content reaches 80%, place it, filter, and recover the ethanol to dryness under reduced pressure to obtain the non-volatile active ingredient extracts of Bupleurum and Goose. Saponin 0.1g.

[0129] Take the sodium stearate of 2.0 times the amount of the above Bupleurum and Gooseberry extract as the matrix, heat it to 100°C to melt, add the above volatile oil extract and non-volatile component extract under heat preservation, stir well, dro...

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PUM

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Abstract

The present invention relates to a Chinese medicine oral preparation-Rekeping for curing common cold. Its active components are volatile oil and saikosaponin respectively extracted from northern bupleurum root and centipeda, and their content is the effective dose for curing said disease, the non-stable volatile oil component can be covered with gamma-cyclodextrin. Said invention is characterized by high-efficiency, quickly-obtaining result and long-acting action.

Description

Technical field [0001] The invention belongs to a medicine for treating colds, in particular to a rekeping cold medicine. Background technique [0002] Rekeping injection is used for general high fever and high fever caused by influenza and other viral epidemics. It is made of 275g of Bupleurum vulgare and 275g of Goose not eating grass as raw materials. Its preparation method is: immerse in water for 24 hours, distill and collect 50 Double the amount of distillate, re-distill the distillate once, collect 900ml of distillate, add 10ml of polysorbate-80, 9g of sodium chloride, add water for injection to 1000ml, stir well, adjust the pH to 5.5, filter, potting, Sterilize and get it. Rekeping injection is used for intramuscular injection, 2-4ml once, twice a day. Its shortcomings are: the drug is inconvenient to use, prone to allergic reactions and myocardial damage, pain at the injection site, and easy induration, which brings great pain to the patient. This preparation fails to us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P31/00
Inventor 李向阳
Owner 郑州市光扬中药开发有限公司
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