44 results about "Gamma-Cyclodextrins" patented technology

An inhalable formulation containing SAE-γ-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-γ-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus. The formulation can include one or more additional therapeutic agents for use in combination with the corticosteroid. SAE-γ-CD is especially useful for solubilizing esterified corticosteroids.

Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and / or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non-diabetic patients, to prevent reactive hypoglycemia in susceptible non-diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and / or to provide a prolonged glycemic response during exercise. The methods are based upon the discovery that gamma-cyclodextrins are rapidly metabolized and absorbed in the small intestine, but subsequently result in a surprisingly blunted postprandial glycemic response and reduced insulin secretion.

The invention relates to a ginkgolide B nanoliposomes drug and a method for preparing the same. The invention provides the ginkgolide B nanoliposomes drug including the following materials and the following radios: 8-12 mol compositions of cephalin and distearoyl choline with mole ratio of 1:3-6; 6-8 mol compositions of sojasterol and cholesterin with mole ratio of 1:2-4; 4-6 mol compositions of gamma-cyclodextrin / 2-hychoxypropyl-beta-cyclodextrin and alpha-cyclodextrin with mole ratio of 3:1; 0.2-0.4 mol methoxy polyethylene glycol 2000-hydrogenated soybean phosphatidylethanolamine; 2 mol ginkgolide B; and 0.1-0.5 mol vitamine E. A method for preparing the ginkgolide B nanoliposomes drug is also provided in the invention to produce the ginkgolide B nanoliposomes for target treating blocking of vessel or endothelial cell thereof, with a better healing effect than ordinary preparations of ginkgolide B.

The invention belongs to the technical field of medicines, and relates to a resveratrol clathrate and a preparation method of resveratrol clathrate preparations, and the method mainly includes the following content: (1) selecting a suitable solvent to dissolve resveratrol; (2) using a modern preparation technology, comprising a saturated water solution method, a grinding method, a freeze drying method, an ultrasonic method, a spray drying method and the like, and a new clathrate material, comprising cyclodextrin or its derivatives such as beta cyclodextrin, hydroxypropyl beta cyclodextrin, alpha cyclodextrin, gamma cyclodextrin, glucosyl beta cyclodextrin and the like, to prepare the resveratrol clathrate; (3) using experiments to optimize a best mass ratio of resveratrol to clathrate material molecule; and (4) preparing the resveratrol clathrate into tablets, capsules, oral liquids and other preparations. By preparation of the resveratrol clathrate and the resveratrol clathrate preparations, the problem of poor water solubility and instability and low bioavailability can be solved.

A liquid preparation includes an etherified cyclodextrin derivative and a substituted benzimidazol, where the etherified cyclodextrin derivative is one of alpha-, beta, and gamma-cyclodextrin ether.

The invention discloses an adsorbing material for removing methylene blue from water, and a method for removing methylene blue from water by using the adsorbing material. The adsorbing material is prepared by the following steps: dispersing graphene oxide into deionized water; adding gamma-cyclodextrin to form mixed liquid; controlling the temperature of the mixed liquid and adjusting the pH value; adding hydrazine hydrate to reduce the graphene oxide to obtain a solid product; and repeatedly washing and centrifuging the product to obtain the adsorbing material. The method for removing the methylene blue from the water by using the adsorbing material comprises the steps of adding the adsorbing material into a methylene blue-containing solution, adjusting the pH value of the mixed solution to be 1-10, placing the mixed solution into a thermostatic oscillator; oscillating for 12 hours, and after adsorption is finished, filtering the residual solution after adsorption by a filter membrane so as to remove methylene blue from water. The graphene / gamma-cyclodextrin composite adsorbing material prepared by the method has high adsorption capacity on the methylene blue in water.

Cosmetic or dermatological preparations are based upon vitamin F, and the vitamin F is present in the form of a complex with a cyclodextrin which includes alpha-cylodextrin, beta-cyclodextrin, and gamma-cyclodextrin.

The present invention relates to a kind of freeze-dried prostaglandin injection and its preparation process and use. It aims at solving the problems of unstable medicine performance and pain produced during injection. The freeze-dried prostaglandin injection consists of prostaglandin, alpha-cyclodextrin, hydroxypropyl-beta-cyclodextrin or gamma-cyclodextrin, Thymosin and Dextran. It has the function of bi-directional immunity regulation, produces less pain, stable quality and stable and high treating effect. It may be also delay released, controlling released and target released.

The invention discloses a method for purifying gamma-cyclodextrin by utilizing cyclodextrin hydrolase and belongs to the technical field of processing of cyclodextrin. The method comprises the following steps of using starch or dextrin as a substrate, using buffer solution to prepare substrate solution with certain concentration, adding a certain amount of cyclodextrin glucosyltransferase with gamma-CD as a product, controlling reaction temperature and reaction time, and after reaction is ended, killing enzyme; using the reaction liquid as a substrate, adding a certain amount of cyclodextrin hydrolase, controlling reaction temperature and reaction time, and after reaction is ended, killing the enzyme. The method disclosed by the invention utilizes the cyclodextrin hydrolase with selectivedegradability to the cyclodextrin and utilizes a higher degradability of the cyclodextrin hydrolase to alpha-CD and beta-CD and a weaker degradability to gamma-CD to selectively remove the alpha-CD and the beta-CD and retain the gamma-CD so as to improve the purity of the gamma-CD. The method disclosed by the invention breaks through the original methods mostly adopting an organic solvent for precipitation in the industry, adopts the method for purifying the gamma-cyclodextrin by an enzymatic method, is simple in operation, is environment-friendly and has good application potential in the field of cyclodextrin processing.

The invention belongs to the technical field of drink processing and relates to a Chinese herbal medicine healthy tea and a preparation method thereof, in particular to a compound antihypertensive healthy tea containing Inonotuso bliquus (Fr ) Pilat and a preparation method of the compound antihypertensive healthy tea containing the Inonotuso bliquus (Fr ) Pilat. The compound antihypertensive healthy tea containing the Inonotuso bliquus (Fr ) Pilat comprises, by weight, 20-50 parts of Inonotuso bliquus (Fr ) Pilat, 10-15 parts of Herba Taxilli, 5-15 parts of Radix Puerariae, 5-15 parts of Rhizoma Chuanxiong, 10-20 parts of wild chrysanthemum flower, 10-20 parts of Spica Prunellae, 5-10 parts of dogbane leaf, 10-20 parts of Ramulus Uncariae Cum Uncis, 10-15 parts of Rhizoma Gastrodiae, 5-10 parts of Rhizoma Pinelliae, 5-10 parts of Semen Cassiae, 0.1-0.7 part of sodium alginate and 0.1-1 part of gamma-cyclodextrin. The compound antihypertensive healthy tea containing the Inonotuso bliquus (Fr ) Pilat, prepared from Chinese herbal medicines, has the efficacies of anti-hypertension, blood fat reduction and detumescence by detoxification, is scientific and reasonable in formula, free from toxic or side effect, mature in preparation technology, natural and green in raw materials and good in drinking and health care functions and can be produced massively.

The invention relates to hinokitiol clathrate compound and a preparation method thereof and specifically relates to the hinokitiol clathrate compound which can obviously improve hinokitiol water solubility and completely solve illumination color change and degradation of the hinokitol and the preparation method thereof. The hinokitiol clathrate compound disclosed by the invention is preferably clathrate compound prepared from the hinokitiol and cyclodextrin or derivative of the cyclodextrin, wherein the cyclodextrin or the derivative thereof is chosen from alpha-cyclodextrin or derivative thereof, beta-cyclodextrin or derivative thereof and gamma-cyclodextrin or derivative thereof, and a mass ratio of the hinokitiol to the cyclodextrin or the derivative thereof is (1 to 8) to (1 to 1000).The preparation method of the hinokitiol clathrate compound is chosen from a precipitation and coprecipitation method, a grinding method, an ultrasonic method, a freeze drying method, a spray drying method, a liquid-liquid method or a liquid-gas method, a solid phase clathration method and the like.

The invention relates to a preparation method of cyclodextrins, which comprises the following steps: (1) preparing a starch slurry; (2) adding alpha-amylase, glucosaccharase and pullulanase into the starch slurry, keeping the temperature to react, adding cyclodextrin glucosyltransferase, reacting for 2-3 hours, and terminating the reaction to obtain a cyclodextrin solution; (3) adding alpha-amylase, glucosaccharase and pullulanase into the cyclodextrin solution, and reacting for 1.5-2 hours to obtain a cyclodextrin crude solution; (4) adding a flocculant and activated carbon into the cyclodextrin crude solution to perform decolorization, carrying out ion exchange and nanofiltration membrane filtration to obtain a cyclodextrin purification solution; and (5) concentrating and drying the cyclodextrin purification solution to obtain the cyclodextrins. Under the condition of not using any organic solvent, the proportion of the alpha-cyclodextrin and gamma-cyclodextrin in the cyclodextrins in the reaction product is greatly enhanced, and the content of beta-cyclodextrin is lower, thereby greatly enhancing the application range and application effect of the cyclodextrins.

The invention provides a novel method for synthesizing hyperpolarized xenon-129 (HP Xe) biosensors by using pseudo-rotaxane structures of gamma-cyclodextrin. These supramolecular complexes form novel ternary structures in the presence of HP Xe which can be detected via 129Xe MR spectroscopy and imaging techniques. The rotaxane-type complex can be tagged with an affinity label for detecting a target in a biological subject.

Methods of forming cyclosporin / cyclodextrin complex nanoparticles and microparticles, and administration of the nano- and micro-suspension formed to an eye of a human or animal in the form of aqueouseye drops suitable to elicit or enhance tear formation and for treatment of diseases of the eye and surrounding areas. The aqueous eye drop composition contains cyclosporin and a mixture of alpha-cyclodextrin and gamma-cyclodextrin as well as one or more stabilizing polymers. Alpha-cyclodextrin solubilizes cyclosporin while gamma-cyclodextrin promotes formation of cyclosporin / cyclodextrin complexaggregates. The polymers stabilize the aqueous nano- and micro-suspension.

The invention relates to a montelukast sodium chewable tablet. The tablet is composed of montelukast sodium, gamma-cyclodextrin, a binder, a disintegrant, a filler and a lubricant. According to the method, a special cavity structure and non-toxic excellent properties of the gamma-cyclodextrin and the characteristic that the gamma-cyclodextrin can be combined with various objects are used for preparing a montelukast sodium clathrate compound, so that the montelukast sodium is protected from light, oxygen and the like due to a cyclodextrin clathrate compound, and the stability of the montelukastsodium tablet is improved. The montelukast sodium is dispersed in the gamma-cyclodextrin, compared with the commonly used direct mixing tabletting process, the risk of uneven distribution of the montelukast sodium in granules is reduced during the production process, and content uniformity of the tablet is obviously improved.

The invention discloses a preparation method of a ceramic water reducing agent. The preparation method comprises the following steps: (1) modifying polyethylene glycol monoallyl ether by utilizing N-[beta-(N,N-diacetoxyl)aminoethyl]-gamma-(N-acetoxyl)aminopropyltrimethoxysilane; (2) preparing a quaternary ammonium salt type 15 polymerized monomer based on 1-(2-(4-aminophenyl)ethyl)amino-1-(hexaglucosyl)deoxysorbitol; (3) polymerizing; (4) modifying octo(6-bromo-6-deoxy)-gamma-cyclodextrin by adenosine disodium triphosphate; (5) preparing the water reducing agent. The ceramic water reducing agent disclosed by the invention has the advantages of strong commonality, small dosage, remarkable water reduction and dispersion effects, good chemical and thermal stability and strong hydration capability.

The invention relates to the field of textile materials and discloses a preparation method of fiber with the humidifying function. The method comprises the following steps of 1, preparing silver-loaded gamma-cyclodextrin; 2 preparing cellulose-fibroin xerogel particles; 3, preparing master batch with the humidifying function; 4 performing spinning. The obtained fiber with the humidifying function has the automatic humidifying effect, is high in response speed, further has the slow-release and antibacterial effects, is long in effectiveness, and will not affect the flexibility and comfortableness of the fiber, and in addition, the strength of the fiber is enhanced.

The present invention relates to a Chinese medicine oral preparation-Rekeping for curing common cold. Its active components are volatile oil and saikosaponin respectively extracted from northern bupleurum root and centipeda, and their content is the effective dose for curing said disease, the non-stable volatile oil component can be covered with gamma-cyclodextrin. Said invention is characterized by high-efficiency, quickly-obtaining result and long-acting action.

The present invention provides a method for the production of γ-CD, comprising making a starch slurry, incubating with γ-CGTase and isoamylase simultaneously for γ-CD production, forming a complex of γ-CD and an organic complexant, and purifying γ-CD from the complexant. The present invention provides a simple and cost-effective method for producing high purity γ-CD, which has a short production cycle, a high conversion rate, and is adaptable to large-scale industrial production.

Disclosed is a platinum complex formula (I) wherein X represents a halogen atom, B represents, independently to each other, a halogen atom, a hydroxyl group or a carboxylate group containing 1 to 6 carbon atoms, and A represents a primary tricyclic amine containing 10 to 14 carbon atoms which may be optionally substituted on the tricyclic ring by one or two alkyl group(s) each containing 1 to 4 carbon atoms, and, furthermore, an inclusion complex of the above platinum complex with beta- or gamma-cyclodextrin which may be optionally substituted by hydroxyalkyl groups containing 1 to 6 carbon atoms. There is also disclosed a process for the manufacture of the complex of formula (I) based on oxidation of a complex of divalent platinum of formula (II) with hydrogen peroxide and on optional substitution of hydroxyl groups in the obtained product with carboxylate groups by action of an acylating agent. The disclosed complexes may be used as such or as a part of pharmaceutical composition in a therapy of oncologic diseases.

A double-enzyme method for improving specificity of gamma-cyclodextrin includes the steps: (1) taking corn starch as a substrate, and subjecting the corn starch to microwave heating until the corn starch is completely dissolved into a Tris-Hcl buffer solution with pH being 8.5 and concentration being 50mmol / L to obtain corn starch solution; (2) respectively adding two enzymes including 4alpha GTase and CGTase into the corn starch solution, controlling reaction temperature and reaction time, and boiling for 30min to inactivate the enzymes after reaction is finished; (3) adding glucamylase into reaction solution, reacting for 16-24h at the temperature of 38 DEG C, and after reaction is finished, boiling for 10min to inactivate the enzymes and centrifuging for 5min at a speed of 10000rpm; (4) obtaining supernatant which is a mixture containing gamma-cyclodextrin. By the double-enzyme method for improving specificity of gamma-cyclodextrin, the problem of low specificity of gamma-cyclodextrin is solved, and application range of gamma-cyclodextrin can be further broadened.

The invention discloses a finasteride tablet for treating hyperplasia of prostate and a preparation method of the finasteride tablet. The tablet is obtained by compressing medicine-containing particles and pharmaceutically acceptable auxiliary materials, wherein the medicine-containing particles are prepared by following steps: dissolving finasteride in polyethylene glycol glyceride octoate decanoate, adding gamma-cyclodextrin into the solution to perform adsorption and then screening to obtain the medicine-containing particles. The finasteride tablet prepared by the preparation method is high in dissolving speed, and the dissolving amount of the finasteride tablet can be higher than 95% in 5 minutes; moreover, the preparation method has the advantages of simple process and easy operation.

The invention relates to a production process of gamma-cyclodextrin through double-enzyme compounding and belongs to the technical field of cyclodextrin production. The production process of the gamma-cyclodextrin through the double-enzyme compounding lowers the production cost of the gamma-cyclodextrin and adopts the technical scheme that the process comprises the steps of utilizing gamma-CGTase (cyclodextrin glycosyltransferase) (A223K) from basophilic bacillus and isoamylase to produce the gamma-cyclodextrin, preparing starch slurry according to a concentration of 5-20%, keeping warm at 60-90 DEG C for 5-15min, setting the temperature to be 40-60 DEG C, regulating pH to be 7.0-8.0, adding 10-100U of gamma-CGTase (A223K) and 10-100U of isoamylase to starch per gram, adding 5%(w / v) of organic solvent, conducting sufficient reaction for 6-12h, recovering the organic solvent, and obtaining the gamma-cyclodextrin by a crystallization method.

The invention discloses a quantitative analysis method of gamma-cyclodextrin (gamma-CD) based on a bromocresol green (BCG) developing method. The measurement method comprises the following experimental steps: (1) a measurement solution is prepared; (2) the light absorption value difference of samples is measured, specifically, a 3 mL of BCG solution with the concentration being 0.35 mmol / L is taken to be added into a 50 mL of brown colorimetric tube, then a 2 mL of gamma-CD solution is added, the constant volume process is conducted to 25 mL through an acetic acid-sodium acetate buffer solution with the pH being being 4.4, after even vibrating, still standing is conducted for 25 min in constant-temperature water bathing at 30 DEG C, then the absorbancy of the gamma-CD solution is measuredwith the buffer solution as the reference at 625 nm, in a blank experiment, 2 mL of distilled water replaces the gamma-CD solution, other experimental operation is the same, and the absorbancy difference (delta A) is equal to the difference between the sample absorbancy (A) and the absorbancy (A') of the blank solution; and (3) a standard curve is drawn, specifically, a 1 mmoL / L gamma-CD solution,a 2 mmoL / L gamma-CD solution, a 3 mmoL / L gamma-CD solution, a 4 mmoL / L gamma-CD solution and a 5 mmoL / L gamma-CD solution are added into tubes correspondingly, the absorption value differences of the1 mmoL / L gamma-CD solution, the 2 mmoL / L gamma-CD solution, the 3 mmoL / L gamma-CD solution, the 4 mmoL / L gamma-CD solution and the 5 mmoL / L gamma-CD solution are measured according to the method, andthen a drawing is made with the concentration of CD as the abscissa and the absorbancy differences (delta A) between the solution of test samples and the blank solution as ordinates to obtain a positive correlation curve as a gamma-CD standard curve.