Coated roxithromycin micro-capsule, and its prepn. method utilizing fluidized bed

Abstract

A coated roxithromycin microsoftgel is disclosed. Its fluidized-bed preparing method features that the solution of the copolymer of dimethylamino ethyl methylacrylate and methylacrylate in alcohol is used as the coating material to coat the roxithromycin in fluidized-bed granulator, and then is dried in hot airflow. Its advantages are no bitter taste, easy absorption in stomach and no environmental pollution.

Description

technical field [0001] The present invention relates to industrial medicament and oral solid preparation. Background technique [0002] Roxithromycin is a macrolide broad-spectrum antibiotic. It is absorbed orally and is stable to gastric acid, but it tastes extremely bitter. Roxithromycin granules and orally dispersible tablets with good dispersibility are needed in medical clinics. Therefore, masking the bitter taste has become its The key technology of preparation. [0003] In industrial pharmacy, there are many methods for improving the bitter taste of medicines. At present, the method of changing the crystal form of the drug and reducing its surface area is commonly used. The technology is simple and economically feasible, but the bitterness masking effect is poor. [0004] Microencapsulation is a new process for wrapping thin films of solid-liquid dispersions. Air suspension method encapsulation of microcapsules is suitable for solid substances. This method was su...

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to disclose a kind of roxithromycin microcapsule with coating, to overcome the defect of poor bitterness masking effect existing in the prior art;