Coated roxithromycin micro-capsule, and its prepn. method utilizing fluidized bed

A roxithromycin and fluidized bed technology, applied in the field of industrial pharmaceuticals and oral solid preparations, can solve problems such as poor bitterness masking effect, and achieve the effects of stable and reliable technical parameters and good operation reproducibility

Inactive Publication Date: 2004-10-20
上海丽珠制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to disclose a kind of roxithromycin microcapsule with coating, to overcome the defect of poor bitterness masking effect existing in the prior art;

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prepare 87 kg of 70% medicinal ethanol solution, add 13.0 kg of dimethylaminoethyl methacrylate and methacrylate copolymer, and stir to completely dissolve it.

[0022] Weigh 25.0 kg of roxithromycin with a fineness of 60-120 mesh, add it into a fluidized bed granulator, and suspend and fluidize it with hot air at 65°C.

[0023] Using a peristaltic pump as the working power, the capsule material solution is continuously atomized through the nozzle to coat the roxithromycin in the fluidized bed at a spray rate of 320 g / min.

[0024] Continue to carry out hot air drying, stop heating after the solution is sprayed, cool and discharge to obtain the coated roxithromycin microcapsules of the present invention.

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Abstract

A coated roxithromycin microsoftgel is disclosed. Its fluidized-bed preparing method features that the solution of the copolymer of dimethylamino ethyl methylacrylate and methylacrylate in alcohol is used as the coating material to coat the roxithromycin in fluidized-bed granulator, and then is dried in hot airflow. Its advantages are no bitter taste, easy absorption in stomach and no environmental pollution.

Description

technical field [0001] The present invention relates to industrial medicament and oral solid preparation. Background technique [0002] Roxithromycin is a macrolide broad-spectrum antibiotic. It is absorbed orally and is stable to gastric acid, but it tastes extremely bitter. Roxithromycin granules and orally dispersible tablets with good dispersibility are needed in medical clinics. Therefore, masking the bitter taste has become its The key technology of preparation. [0003] In industrial pharmacy, there are many methods for improving the bitter taste of medicines. At present, the method of changing the crystal form of the drug and reducing its surface area is commonly used. The technology is simple and economically feasible, but the bitterness masking effect is poor. [0004] Microencapsulation is a new process for wrapping thin films of solid-liquid dispersions. Air suspension method encapsulation of microcapsules is suitable for solid substances. This method was su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/7048A61P31/04
Inventor 王承炜王文荇刘秀英郑良元钱陈钦
Owner 上海丽珠制药有限公司
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