Novel production method of naphtha of rhizome of Sichuan lovage

The technology of volatile oil of Chuanxiong and Chuanxiong, which is applied in the field of medicine, can solve the problems of high content of impurity unsaturated long-chain fatty acids, difficult control of operating conditions, difficult retention of active components, etc., and achieves mild extraction conditions, no solvent residue, and easy control of operating conditions. Effect

Inactive Publication Date: 2004-11-17
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Problems solved by technology

[0003] Chuanxiong has pharmacological effects such as relieving vasospasm, dilating blood vessels, improving blood circulation, and relieving congestion or insufficient blood supply. Currently, the most common methods of using Chuanxiong to treat ischemic stroke are water decoction or water extraction and alcohol precipitation. This preparation method makes it difficult to retain the active ingredients in the volatile part of the raw material drug, thus affecting the curative effect
At present, the method of extracting the volatile oil of Rhizoma Chuanxiong by supercritical carbon dioxide fluid extraction technology [see Yuan Yongfang, Zhou Jian, Zheng Xiaomei, etc. for details. Supercritical fluid CO 2 Study on the extraction of chemical constituents of the volatile oil of Rhizoma Chuanxiong [J]. Chinese Journal of Pharmaceutical Sciences, 2000, 35(2): 84]. The extraction conditions are as high as 34.5MPa, 60°C, far away from the critical point of carbon dioxide, the pressure is 7.185MPa and the temperature is 31.1 ℃, so that the obtained volatile oil has a darker color and redness, which is obviously different from the light yellow volatile oil obtained by steam distillation. The content of impurity unsaturated long-chain fatty acids in the volatile oil obtained by SFE is higher as determined by GC-MS. There is a considerable difference from the oil obtained by steam distillation, and due to the high extraction pressure, the operating conditions are not easy to control, and the loss of equipment is relatively large

Method used

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  • Novel production method of naphtha of rhizome of Sichuan lovage

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Embodiment 1

[0008] Embodiment 1: Preparation of Rhizoma Chuanxiong Volatile Oil

[0009] 1. Raw material preparation: wash the Ligusticum chuanxiong with clean water, dry it at 30°C at low temperature, and grind it into a 20-mesh fine powder with a pulverizer;

[0010] 2. Extraction: Get 500g of Ligusticum chuanxiong fine powder, and use a carbon dioxide fluid extraction device (Nantong Huaan supercritical fluid extraction apparatus, the same below) to extract volatile oil. The extraction temperature is 20°C, the extraction pressure is 7.2Mpa, and the extraction time is one and a half hours. Get 15ml of volatile oil.

Embodiment 2

[0011] Embodiment 2: Preparation of Rhizoma Chuanxiong Volatile Oil

[0012] 1. Raw material preparation: wash the Ligusticum chuanxiong with clean water, dry at 40°C at a low temperature, and grind it into a 20-mesh fine powder with a pulverizer;

[0013] 2. Extraction: Take 500g of Ligusticum chuanxiong fine powder, extract the volatile oil with a carbon dioxide fluid extraction device, the extraction temperature is 25°C, the extraction pressure is 7.0Mpa, the extraction time is one and a half hours, and 14ml of volatile oil is obtained.

Embodiment 3

[0014] Embodiment 3: Preparation of Rhizoma Chuanxiong Volatile Oil

[0015] 1. Raw material preparation: wash the Ligusticum chuanxiong with clean water, dry it at 30°C at low temperature, and grind it into a 20-mesh fine powder with a pulverizer;

[0016] 2. Extraction: Take 500g of Ligusticum chuanxiong fine powder, extract the volatile oil with a carbon dioxide fluid extraction device, the extraction temperature is 20°C, the extraction pressure is 7.5Mpa, the extraction time is two and a half hours, and 18ml of volatile oil is obtained.

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Abstract

The invention relates to the field of pharmaceutical, in particular a novel process for preparing Ligusticum wallichii volatile oil, which comprises drying the Ligusticum wallichii raw material, disintegrating, employing subcritical carbon dioxide carbon dioxide extraction. The prepared Ligusticum wallichii volatile oil according to the invention can be applied into the preparation of medicament for treating cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a new preparation method for preparing chuanxiong volatile oil from traditional Chinese medicine chuanxiong. Background technique [0002] At present, there are many medicines for the prevention and treatment of ischemic encephalopathy at home and abroad, but the curative effect is not satisfactory. Searching for drugs to prevent and treat ischemic encephalopathy from traditional Chinese medicine has become a research hotspot both at home and abroad. Ischemic encephalopathy, such as the most common cerebral thrombosis, belongs to the category of "congestion" in Chinese medicine. [0003] Chuanxiong has pharmacological effects such as relieving vasospasm, dilating blood vessels, improving blood circulation, and relieving congestion or insufficient blood supply. Currently, the most common methods of using Chuanxiong to treat ischemic stroke are water dec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P9/00C11B1/10
Inventor 胡晋红高丽红郑晓梅张万国
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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