Cefuroxime, beta-lactamase inhibitor containing composition

A technology of cefuroxime and lactamase, which is applied in the direction of antibacterial drugs, can solve the problems affecting clinical anti-infection treatment and the rising rate of resistance to β-lactam antibiotics

Inactive Publication Date: 2004-12-29
SUZHOU DAWNRAYS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Cefuroxime is a second-generation cephalosporin with broad-spectrum antibacterial effect. In recent years, due to the widespread emergence of clinical β-lactamase-producing strains, especially the emergence of extended-spectrum β-lactamase, β-lactams The rate of antibiotic resistance continues to rise, which seriously affects the clinical anti-infective treatment

Method used

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  • Cefuroxime, beta-lactamase inhibitor containing composition
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  • Cefuroxime, beta-lactamase inhibitor containing composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: cefuroxime sodium sulbactam sodium (0.75g / 0.75g) powder injection for injection

[0030] Take cefuroxime sodium (calculated as cefuroxime) and sodium sulbactam (calculated as sulbactam) respectively and mix them uniformly in a mixer according to the technical specifications of aseptic operation in a 1:1 weight ratio, and mix them in a local 100-level environment. The lower part is packed in the sterilized vial, and the stopper and cap are obtained to obtain cefuroxime sodium sulbactam sodium powder injection for injection.

Embodiment 2

[0031] Embodiment 2: cefuroxime sodium sulbactam sodium for injection (0.75g / 0.75g) freeze-dried preparation

[0032] Dissolve cefuroxime sodium (calculated as cefuroxime) and sodium sulbactam (calculated as sulbactam) in an appropriate amount of water for injection at a weight ratio of 1:1, filter and sterilize with a 0.22 μm microporous membrane , put it on a plate, and pre-freeze at 1°C / min until the temperature drops to -35°C for 2 hours, and then heat it up to -5°C at a rate of 5°C / hour under the condition of a condensing -32°C drying oven with a vacuum of 200 , maintained for 20 hours, and raised to 10°C, maintained for 10 hours. Then put on the plug and press the cap to obtain the freeze-dried preparation of cefuroxime sodium sulbactam sodium for injection.

Embodiment 3

[0033] Embodiment 3: cefuroxime sodium sulbactam sodium powder for injection (0.75g / 0.325g)

[0034] Cefuroxime sodium sulbactam sodium (2:1) powder injection was prepared according to the operation procedure and process of Example 1.

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Abstract

The present invention is one kind of antiseptic medicine composition containing antibiotic cefuroxime and beta-lactamase inhibitor in the weight ratio of 0.5-20. The said medicine composition as new generation of antiseptic medicine composition has the advantages of wide antiseptic spectrum and strong antiseptic effect.

Description

technical field [0001] The invention relates to β-lactam antibiotics, in particular to a novel compound antibiotic composed of cefuroxime drugs and β-lactamase inhibitors. The composition has strong effects on sensitive bacteria and enzyme-producing bacteria, and has wider antibacterial spectrum and stronger antibacterial effect. Background technique [0002] Bacterial drug resistance is a natural selection for bacteria to submit to the selective pressure of antibiotics and continue. The main mechanism is that bacteria produce β-lactamase, which acts on β-lactam antibiotics to open the β-lactam ring and Inactivate. This kind of drug resistance can not only spread between bacteria, but also spread around the world. Infections caused by drug-resistant strains are often refractory or even fatal. Therefore, the research on the trend of bacterial drug resistance and New antibacterial means have become a long-term and even eternal topic for human beings to protect their own exis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61P31/04
Inventor 初虹
Owner SUZHOU DAWNRAYS PHARM CO LTD
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