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Nimodipine injection emulsion and its preparing method

The technology of nimodipine and nimodipine is applied in the field of injection emulsion medicine and its preparation, and can solve the problems of iatrogenic pollution, difficulty in controlling the dripping speed of two-way intubation, inconvenience and the like

Inactive Publication Date: 2005-01-12
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These two drugs can only be administered together with other infusions in clinical use through two-way intubation. convenient
At the same time, this way of administration is also likely to cause iatrogenic pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Dissolve 0.1g of nimodipine, 12g of refined soybean lecithin in 100g of refined soybean oil, dissolve 22.5g of glycerin in water for injection, heat to 55°C respectively, mix well, and disperse and emulsify in a tissue masher for 3-4 Minutes later, it is emulsified by a high-speed homogenizer until the milk particles meet the requirements of the Pharmacopoeia (no less than 95% of the milk particles below 2 μm, and the milk particles above 52 μm cannot be detected), and then add water for injection to 1000 ml. Cool, fill, and sterilize to obtain the nimodipine injection emulsion. This process is a 1000ml prescription, and the production can be expanded, and nitrogen protection is required during the production process.

Embodiment 2

[0021] Add 6g of refined egg yolk lecithin into 50g of xylitol solution, heat to 50°C, first stir 3 times with a tissue grinder at 8000-12000 rpm for dispersion, then add 0.08g of nimodipine and refined large Add 50g of soybean oil into the oil solution, stir 3 times under the same rotational speed to emulsify and disperse, emulsify in the same way as the above example, and then emulsify through the high-speed homogenizer to meet the requirements of the Pharmacopoeia, add water for injection to a sufficient amount, cool the emulsion, and fill it. Sterilize the nimodipine injection emulsion.

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PUM

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Abstract

A nimodipine injection in the form of emulsion for treating hemorrhagic cerebrovascular diseases, hypertension, senile dementia, etc is prepared from nimodipine, plant oil for injection, emulsifier and isotonic regulator through dissolving nimodipine in said plant oil and proportionally mixing others.

Description

technical field [0001] The invention relates to an injection emulsion medicine and a preparation method thereof. The drug is nimodipine injection emulsion, which can be used for ischemic cerebrovascular diseases, such as cerebral vasospasm after various causes of subarachnoid hemorrhage, improvement of blood circulation in the recovery period of acute cerebrovascular diseases, hypertension, prevention and treatment of senile dementia, etc. disease treatment. Background technique [0002] Nimodipine is a kind of fat-soluble chemical medicine, has extremely strong hydrophobicity, has brought great technical difficulty to the manufacture of intravenous injection preparation, and current solution is to add ethanol, poly Ethylene glycol 400 and other organic solvents are used to aid dissolution, and then a central venous catheter and an infusion pump are used for treatment. In addition to the high price of central venous catheters and infusion pumps, which greatly increases the...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/4422A61P9/12A61P25/20
Inventor 欧苏黄英华郁东梅梁隆程志鹏
Owner SICHUAN KELUN PHARMA CO LTD
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