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Preparing method and usage of vitamin E clathrate

A vitamin and clathrate technology, applied in the field of vitamin E clathrate preparation and application, can solve problems such as inability to improve vitamin E absorption, plasticity change, unfavorable long-term storage, etc.

Inactive Publication Date: 2005-01-26
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Vitamin E is a typical fat-soluble vitamin, which contains unsaturated double bonds in its structure. Affected by light, air and temperature, the plasticity will change over time, which is not conducive to long-term storage
In order to improve the stability of vitamin E, vitamin E and inert materials are mixed to make vitamin E powder. Although the above methods can improve the stability, they cannot improve the absorption of vitamin E in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Preparation of solution-type vitamin E hydroxypropyl-β-cyclodextrin inclusion compound

[0023] (1) Weigh 210g (0.154mol) of hydroxypropyl-β-cyclodextrin, pour it into 800ml of distilled water, and stir to dissolve;

[0024] (2) Another 7g (0.0148mol) of vitamin E was weighed and poured into the above-mentioned hydroxypropyl-β-cyclodextrin solution;

[0025] (3) The mixed solution is stirred for 2 hours by magnetic stirring method, and the solution is observed until it becomes clear, and the vitamin E hydroxypropyl-β-cyclodextrin inclusion compound is obtained;

[0026] (4) Pack the clathrate solution into ampoules, ventilate with nitrogen, and melt seal.

Embodiment 2

[0027] Example 2: Preparation of Solid Vitamin E Hydroxypropyl-β-cyclodextrin Inclusion Compound by Freeze-drying

[0028] (1) Weigh 143.3g (0.105mol) of hydroxypropyl-β-cyclodextrin, pour it into 600ml of distilled water, and stir to dissolve;

[0029] (2) Another 7g (0.0148mol) of vitamin E was weighed and poured into the above-mentioned hydroxypropyl-β-cyclodextrin solution;

[0030] (3) The mixed solution was stirred by magnetic stirring for 2 hours, observed until the solution became clear, then the clathrate solution was filtered, freeze-dried, and water was removed to obtain solid vitamin E hydroxypropyl-β-cyclodextrin clathrate.

Embodiment 3

[0031] Example 3: Preparation of Solid Vitamin E Hydroxypropyl-β-Cyclodextrin Inclusion Compound by Spray Drying Method

[0032] (1) Weigh 143.3g (0.105mol) of hydroxypropyl-β-cyclodextrin, pour it into 600ml of distilled water, and stir to dissolve;

[0033] (2) Another 7g (0.0148mol) of vitamin E was weighed and poured into the above-mentioned hydroxypropyl-β-cyclodextrin solution;

[0034] (3) The mixed solution was stirred for 2 hours by magnetic stirring method, and the solution was observed until it became clear, then the clathrate solution was concentrated under reduced pressure to a solid content of 10% to 50%, and then spray-dried to obtain solid vitamin E hydroxypropyl-β- Cyclodextrin inclusion complex.

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PUM

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Abstract

The invention provides the cyclodextrin of vitamin E or cyclodextrin derivative clathrate compound and their preparing process, and their use in preparing pharmaceutical preparations and cosmetics. By utilizing the bundling action of the cyclodextrin or cyclodextrin derivative to vitamin E, the stability and water-solubility of the vitamin E can be increased.

Description

technical field [0001] The present invention relates to cyclodextrin or cyclodextrin derivative inclusion compound of vitamin E and its preparation method, as well as its application in the preparation of pharmaceutical preparations and cosmetics. technical background [0002] Vitamin E chemical name (±)-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol acetate, Molecular formula: C 31 h 52 o 3 The molecular weight is 472.75. This product is a light yellow or yellow transparent viscous oily liquid insoluble in water. It is easily oxidized and turns dark red when exposed to air and light. It can be miscible with acetone, ether or vegetable oil, easily soluble in ethanol, and almost insoluble in water. . [0003] Vitamin E can maintain the normal function of reproductive organs, the normal metabolism of muscles, and prevent the excessive oxidation of unsaturated acids. Protect cells from harmful substances produced by the oxidation of unsatu...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/48A61K31/355A61K47/40A61P3/02
Inventor 李建青周桂荣张宏武李云立申东民容彦华
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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