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Preparation method for sulfadoxine

A technology of sulfonamide and sulfonamide, which is applied in organic chemistry, antibacterial drugs, anti-infective drugs, etc., can solve the problems of high heavy metal content and hazards of sulfonamide

Inactive Publication Date: 2005-01-26
CHANGSHU NANHU INDAL CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] The heavy metal content of the above-mentioned sulfonamides is relatively high, and heavy metals are harmful to the human body after ingestion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0015] (1) Put 250Kg N, N dimethylformamide (DMF) into the dry reaction pot, add 80Kg sulfasulfonamide sodium salt while stirring, then drop into 80Kg 5-methoxy- 4.6-dichloropyrimidine, then put in 80Kg sulfanilamide, and add 10Kg solid alkali. Tighten the lid of the pot, measure the pH value at 10, naturally raise the temperature to 60°C, then measure the pH to 10, raise the temperature to 90°C, keep it warm for 90 minutes, turn on the high-pressure vacuum pump to recover N and N dimethylformamide (DMF) under reduced pressure, and recycle Add 300Kg of pure water at 100°C to the obtained 230Kg N, N dimethylformamide (DMF), press into the cooling pot after all the materials are dissolved, dilute to 1500 liters with pure water, adjust the pH to 7.2, and then cool to 15°C Separation of sulfonamide, and then rinse with pure water until the mother liquor reaches 2000 liters, pumped into the sedimentation pot, acidified with 15% hydrochloric acid at 70°C, and controlled the pH value...

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PUM

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Abstract

Disclosed is the preparation method for sulfadoxine consisting a condensation reaction and a methyl oxidation reaction, wherein the former consists of charging N,N-dimethyl formamide, sulfonamide sodium salt, chloride into dried reaction container proportionally, then charging sulfonamide sodium salt, solid caustic soda, measuring pH=10, elevating the temperature and measuring pH=10 again, then carrying out in turn heating, heat preservation, recovering, dissolving, diluting, adjusting pH, cooling down, separating, acidifying, adjusting pH, dewatering, scouring and drying.

Description

technical field [0001] The invention relates to a preparation method of sulfonamide, which is an improvement to the existing preparation method of sulfonamide, and belongs to the technical field of sulfonamide preparation. Background technique [0002] Zhouxiao sulfonamide (sulfonamide o-dimethoxine) is white or off-white crystalline powder, slightly bitter taste, odorless, gradually changing color when exposed to light, slightly soluble in water, methanol, ethanol, insoluble in ether, soluble in hydroxide Among sodium and dilute inorganic acids, it belongs to sulfa drugs. It can be used to treat pulmonary tuberculosis, lymphatic tuberculosis, malaria, etc., and our country has included it in the "China High-tech Product Export Catalogue" (2003) [7] middle. [0003] The results of literature search show that: China Zhejiang Yuyao Laike Bioengineering Co., Ltd., China Jiangsu Changshu Jinbai Medical Products Co., Ltd., China Zhejiang Ningbo Jinlu Sprayer Chemical Co., Ltd. ...

Claims

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Application Information

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IPC IPC(8): A61P31/06A61P33/06C07D239/52
Inventor 陆永林
Owner CHANGSHU NANHU INDAL CHEM
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