Compositions and methods for treating neurodegenerative diseases
A composition and neuron injury technology, applied in the field of neuron injury, can solve problems such as unclear reverse transport
Inactive Publication Date: 2005-02-02
MITSUBISHI TANABE PHARMA CORP
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Furthermore, it is unclear whether vector-derived GDNF is retroported
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Compositions and methods for treating patients with pre-existing neuronal damage are disclosed. The compositions and methods use an adeno-associated virus (AAV)-based gene delivery system to deliver glial cell line-derived neurotrophic factor (GDNF) to patients with neurodegenerative disorders such as Parkinson's disease .
Description
technical field The present invention generally relates to compositions and methods for gene delivery. In particular, the present invention relates to the delivery of glial cell line-derived neurotrophic factor (GDNF) using adeno-associated virus as a vector gene delivery system to treat pre-existing neuronal damage caused by neurodegenerative diseases, such as Parkinson's disease. Background of the invention Diseases of the central nervous system are major public health problems. Parkinson's disease (PD) affects more than one million people in the United States alone. PD is clinically manifested by decreased voluntary movement, difficulty walking, postural instability, stiffness, and tremor. PD is a progressive neurodegenerative disorder that primarily affects dopaminergic (DA) neurons in the substantia nigra (SN). Currently, a variety of central nervous system diseases are treated by systemic administration of therapeutic drugs. But systemic administration is often ine...
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Login to view more IPC IPC(8): A61K48/00A61K35/76A61K38/18A61P25/00A61P25/16A61P25/28C07K14/475C12N15/12
CPCC12N2799/025A61K38/185C07K14/475A61K48/00A61P25/00A61P25/16A61P25/28
Inventor 小泽敬也村松慎一池口邦彦中野今治
Owner MITSUBISHI TANABE PHARMA CORP
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