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Frozen dry powder injection of houttuynia cordata and its preparation

A technology of freeze-dried powder injection and Houttuynia cordata, which is applied in the field of freeze-dried powder injection of Houttuynia cordata and its preparation, and can solve problems such as adverse reactions, poor novelty, and unstable preparation quality

Inactive Publication Date: 2005-02-23
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Houttuynia cordata preparations that are widely used clinically now include Houttuynia cordata injection and Houttuynia cordata sodium preparations. The former is an injection prepared from the volatile oil extracted from Houttuynia cordata. Because of the properties of the volatile oil of Houttuynia cordata, Its preparations often appear turbid, oil droplets, etc., greatly reducing its quality and pharmacological efficacy; the latter belongs to synthetic chemicals, and adverse reactions caused by the instability of Houttuyfonate Sodium often appear in clinical practice, which brings great harm to patients. The patent application number is 96117459 "a kind of Houttuynia cordata injection and its preparation method" which adopts the steam distillation method to extract the effective parts of Houttuynia cordata and prepares it into injection. The novelty of the present invention is relatively Poor, in terms of preparation, the present invention is prepared as an injection, which also has the disadvantages of unstable preparation quality and reduced pharmacological efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] (1) Get 10,000 grams of Houttuynia cordata and crush it, pass through a 30-mesh sieve, put it into the extraction kettle in the CO2 supercritical extractor, adjust the pressure of the extraction kettle to 15Mpa, the extraction temperature is 30°C, and the flow rate is 50Kg / h. The pressure of 1 and 2 is 3Mpa, the analysis temperature is 20°C, extract for 60 minutes, combine the materials of analysis kettle 1 and 2, and set aside; take the materials of above analysis kettle 1 and 2, and use saturated aqueous solution method to use 2-hydroxypropyl- β-cyclodextrin for inclusion: Weigh 2-hydroxypropyl-β-cyclodextrin, add water at a ratio of 20ml / g, heat to dissolve, cool to room temperature, according to Houttuynia cordata extract: 2-hydroxypropyl -β-cyclodextrin=1:4 ratio (v / g) was added to Houttuynia cordata extract, stirred for 40 minutes, taken out and cooled for 20 hours, centrifuged, filtered, and the filter residue was dried at room temperature for 36 hours to obtain H...

Embodiment 2

[0063] (1) Get 100 kilograms of Houttuynia cordata pulverizers, cross a 50-mesh sieve, put into the extraction kettle in the CO2 supercritical extractor, adjust the pressure of the extraction kettle to 25Mpa, the extraction temperature is 50°C, and the flow rate is 60Kg / h. The pressure of 1 and 2 is 5Mpa, the analysis temperature is 30°C, extract for 100 minutes, combine the materials of analysis kettle 1 and 2, and set aside; take the materials of above analysis kettle 1 and 2, and use saturated aqueous solution method to use 2-hydroxypropyl- β-cyclodextrin for inclusion: Weigh 2-hydroxypropyl-β-cyclodextrin, add water at a ratio of 30ml / g, heat to dissolve, cool to room temperature, according to Houttuynia cordata extract: 2-hydroxypropyl -β-cyclodextrin=1:10 ratio (v / g) was added to Houttuynia cordata extract, stirred for 80 minutes, taken out and cooled for 24 hours, centrifuged, filtered, and the filter residue was dried at room temperature for 48 hours to obtain Houttuyni...

Embodiment 3

[0068] (1) Get 100 kilograms of Houttuynia cordata pulverizers, cross a 40-mesh sieve, put into the extraction kettle in the CO2 supercritical extractor, adjust the pressure of the extraction kettle to 18Mpa, the extraction temperature is 35°C, and the flow rate is 52Kg / h. The pressure of 1 and 2 is 4Mpa, the analysis temperature is 25°C, extract for 65 minutes, combine the materials of analysis kettle 1 and 2, and set aside; take the materials of above analysis kettle 1 and 2, and use saturated aqueous solution method to use 2-hydroxypropyl- β-cyclodextrin for inclusion: Weigh 2-hydroxypropyl-β-cyclodextrin, add water at a ratio of 25ml / g, heat to dissolve, cool to room temperature, according to Houttuynia cordata extract: 2-hydroxypropyl -β-cyclodextrin=1:5 ratio (v / g) was added to Houttuynia cordata extract, stirred for 50 minutes, taken out and cooled for 22 hours, centrifuged, filtered, and the filter residue was dried at room temperature for 40 hours to obtain Houttuynia ...

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Abstract

A freeze-dried powder injection is prepared from houttuynia through extracting its volatile oil and mixing it with 2-hydroxypropyl-beta-cyclodextrin.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a freeze-dried powder injection of Houttuynia cordata and a preparation method thereof. technical background [0002] Houttuynia cordata is the whole herb of Houttuynia cordata Thunb, a plant of the genus Houttuynia cordata Thunb in the family Sanbaiaceae, and it was first recorded in "Famous Doctors". Spicy in taste and cool in nature, it has the effects of clearing heat and detoxifying, eliminating carbuncle and discharging pus, diuresis and treating stranguria. Because of its antibacterial, antiviral, antiallergic, antitumor, anti-inflammatory, pain-relieving, enhancing immune function, anti-Leptospira, diuretic and other effects, it is widely used in clinics. Modern pharmacological studies have shown that the effects of Houttuynia cordata are: 1. Respiratory system disease application; 2. Digestive system disease application; 3. Urin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61P1/00A61P11/00A61P13/00A61P15/00A61P31/00A61P31/22A61P35/00
Inventor 张晴龙
Owner 张晴龙
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