Non-toxic ionic liquid, preparation method and its application

An ionic liquid and anion technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of complex preparation process, toxicity, side effects on human body, etc., and achieve simple preparation process, good solubilization and solubilization, Wide range of effects in the liquid phase

Inactive Publication Date: 2005-08-10
HEBEI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most common ionic liquids mentioned above, such as: 1-methyl-3-butylimidazolium hexafluorophosphate, will be hydrolyzed in water to produce volatile and toxic HF and POF 3 , (R.P.Swalowski, J.D.Holbery, and R.D.Rogers, Green Chem., 2003, 5, 361.); 1-methyl-3-butylimidazole tetrafluoroborate its acute toxicity LD 50 =1.4g/kg (female rat), LD 50 =1.37g/kg (male rat) (J.Pernak, et.al., Ind.Eng.Chem.Res.2001, 40, 2379.), therefore, these commonly used ionic liquids all have certain toxicity, Cannot be used in medicine or as a food additive
In addition, in the pharmaceutical industry, there are many drugs that are insoluble in water and are difficult to be absorbed and utilized by the human body. Therefore, solving the solubility of insoluble drugs in water and improving the bioavailability of

Method used

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  • Non-toxic ionic liquid, preparation method and its application
  • Non-toxic ionic liquid, preparation method and its application

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0031] Example 1 Preparation of L-lactate choline ionic liquid

[0032] Synthesis according to ionic liquid preparation method 1: Add 9.6ml 90% L-lactic acid solution dropwise to 32ml choline hydroxide 45% methanol solution. After stirring for 0.5 hours, after purification, the solvent is evaporated to dryness under high vacuum at 45°C. , Get 22.0g colorless L-lactate choline ionic liquid.

Example Embodiment

[0033] Example 2 Preparation of DL-lactate choline ionic liquid

[0034] Synthesis according to ionic liquid preparation method 1: Add 11.0ml 80% DL-lactic acid solution dropwise to 32ml choline hydroxide 45% methanol solution, stir for 0.5 hours, after purification, the solvent is evaporated to dryness under high vacuum at 45℃ 22.3g. Colorless DL-lactate choline ionic liquid.

Example Embodiment

[0035] Example 3 Preparation of Choline Isobutyrate Ionic Liquid

[0036] Synthesis according to ionic liquid preparation method 1: To 20ml choline hydroxide 45% methanol solution, add 6.14g isobutyric acid dropwise, stir for 0.5 hours, after purification, the solvent is evaporated to dryness under high vacuum and reduced pressure at 45℃ to get 15.4 g Colorless choline isobutyrate ionic liquid.

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Abstract

A non-toxic ionic liquid used as the solvent, cosolvent, or surfactant for increasing the water-solubility of the medicines difficult to dissolve in water features that its cation is alkylimidazole salt with short carbon chain or quaternary ammonium salt.

Description

technical field [0001] The invention belongs to the synthesis of new ionic liquid in the field of chemical materials and its manufacture and the application in the field of medicine as a new solvent, co-solvent or surfactant. Background technique [0002] Ionic Liquids (Ionic Liquids) refer to positive ions such as organic alkylimidazoles, quaternary ammonium salts, and alkylpyridines and different negative ions such as chloride ions, BF 4 - , PF 6 - , CF 3 CO 2 - , N(CN) - 2 Many of them are liquid at room temperature or even at low temperature, so they are also called room temperature ionic liquids. Ionic liquids have the characteristics of no vapor pressure, good thermal stability (up to 300-400°C), good electrical conductivity, and are suitable for organic compounds, inorganic compounds, metal organic compounds, gases (H 2 , CO, O 2 etc.) have a wide range of solubility, can be miscible or insoluble with organic solvents, water to form a two-phase or multi-phas...

Claims

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Application Information

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IPC IPC(8): A61K47/22
Inventor 刘庆彬张占辉张福军
Owner HEBEI NORMAL UNIV
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