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Andrographolide fatty microglobule agent and its preparation method

A technology of andrographolide and lipid microspheres, which is applied in the field of medicine, can solve problems such as literature and patent reports of andrographolide lipid microsphere preparations that have not yet been seen, and achieve reduction of normal tissue distribution, improvement of drug compliance, and reduction of drug administration volume effect

Inactive Publication Date: 2005-10-26
四川思达康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no literature and patent reports on andrographolide lipid microsphere preparations at home and abroad

Method used

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  • Andrographolide fatty microglobule agent and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Put 1.5 g of soybean lecithin for injection and 2.5 g of glycerol for injection into a high-speed tissue grinder, add an appropriate amount of water for injection, and prepare a uniform dispersed phase at a speed of 12,000 rpm; mix the dispersed phase with Andrographis paniculata Preheat 10 ml of oil for injection with 250 mg of lactone to 60-80°C respectively, mix them to make colostrum, add water for injection to 100 ml of colostrum, put it into a high-pressure homogenizer for repeated emulsification, and pass through 3 micron pores Filtrate through a filter membrane, fill with nitrogen, and sterilize to obtain lipid microsphere preparation milk for intravenous injection, which can also be taken orally.

Embodiment 2

[0035] Example 2 Soybean Lecithin for Injection 1.2g, Pluronic (F-68) 0.3g and Water for Injection were first prepared into a uniform dispersed phase; adding 10 ml of preheated andrographolide dissolved in 25 mg of oil for injection was prepared Colostrum, add water for injection to make up to 100 ml; high-pressure emulsification, filter through a 0.8 micron microporous membrane, fill with nitrogen, and sterilize to prepare the lipid microsphere preparation for intravenous injection.

Embodiment 3

[0036] Example 3 Prepare 1.5 g of soybean lecithin for injection, 2.5 g of glycerol for injection and water for injection to form a uniform dispersed phase; add 20 ml of preheated oil for injection dissolved with 25 mg of andrographolide to make colostrum, add injection Make up to 100 ml with water, emulsify under high pressure, and fill with nitrogen to prepare intravenous lipid microsphere preparation.

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Abstract

A lipid microsphere of andrographolide is prepared from andrographolide as active component, the oil for injection or medicine, emulsifier and the water for injection or medicine. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an andrographolide lipid microsphere preparation and a preparation method thereof, belonging to the field of medicines. Background technique [0002] Andrographolide is a diterpene lactone compound extracted from Andrographis paniculata (Burm.f.) Nees, a plant of the Acanthaceae family. It is one of the main active ingredients of the traditional Chinese medicine Andrographolide. , has a special effect on bacterial and viral upper respiratory tract infections and dysentery, and is known as a natural antibiotic drug. Modern pharmacological studies have shown that andrographolide has the functions of antibacterial and anti-inflammatory, anti-viral infection, anti-tumor, anti-cardiovascular disease, and immune stimulation. (Pharmacological research progress of andrographolide and its derivatives, Liu Xinjian et al., Chinese Materia Medica Vol. 26, No. 2, February 2003; Clinical Observation of Andrographolide Tablets in Treating Up...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365
Inventor 毛声俊金辉梁臻吴宇
Owner 四川思达康药业有限公司
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