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Biologic skin repair and enhancement

A technology for skin, angiogenic factors, applied in the field of repair and/or enhancement of skin, which can solve problems such as small-scale temporary improvement that many people do not apply

Inactive Publication Date: 2005-11-23
彼得 K 罗
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technique is also usually limited to small temporary improvements and does not work for many people

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] It has been found that myoblasts from a cream-like suspension can be applied in a thin layer (one or more layers) to a prepared skin surface to allow the myoblasts to survive, grow and incorporate into the skin, thereby filling the Fissures and other fissures in the skin. Myoblasts smooth out imperfections in the skin and provide more properties such as elasticity and even color and strength.

[0009] In an advantageous embodiment, the skin of the individual to be treated is first treated, preferably with a smooth abrasive or with one or more chemicals such as lactic acid. Following the treatment to remove dead cells, the myoblast suspension, with or without foreskin fibroblasts, is blotted onto the desired area to fill in blemishes, wrinkles and / or holes. Warm, moist oxygenated air, or more preferably pure oxygen, is then blown over the treated area for at least 0.1, 1, 3, 6, 12, 24 or more hours. Leave the area on for at least 12, 24 to 30 or more hours. The entire...

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PUM

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Abstract

Muscle cell materials and methods are provided for refurbishing skin. Skin surfaces are prepared by removing dead cells and myoblasts are added in a cell-nutritive solution. An embodiment provides autologous human myoblast cells from the individual to be treated, serum from the individual, and an angiogenesis factor for stimulation of vascularization. Large 6 chondroitin sulfate may be used for controlled rapid cell fusion of the myoblasts. Foreskin fibroblast cell suspensions also may be used singly or in combination with myoblasts. In yet another embodiment non-immunogenic cells from another animal such as a pig with a double knockout mutation that affects foreign recognition may be added to cell surfaces.

Description

[0001] This application claims priority to US Provisional Application Serial No. 60 / 405,301, filed August 23, 2002, which is hereby incorporated by reference in its entirety. technical field [0002] The present invention relates generally to the repair of skin, and more particularly to the use of living cells to repair and / or enhance skin. Background technique [0003] Skin ages naturally with the passage of time. Aging is accelerated by the action of sunlight, a process known as photoaging, but also by exposure to wind, salt, and other factors. As it ages, the skin possesses or exhibits various problems including lines, wrinkles, lack of firmness and elasticity, roughness, uneven stratum corneum, age spots and actinic keratosis. [0004] Cosmetics that temporarily enhance the appearance of the skin by masking imperfections with opaque cosmetic films or coatings have been used for thousands of years. Treatments that improve the quality and appearance of bare, unmodified s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K31/715A61K35/34A61K35/57A61L27/38A61L27/60A61Q19/00C12N5/077
CPCA61K35/34C12N2501/13A61K38/1866C12N2501/165A61K38/28A61K8/981A61K31/715A61Q19/08A61K38/185C12N2501/15C12N2501/33A61K2800/28C12N5/0658C12N2500/80A61L27/3826A61L27/60A61K8/99A61L27/383A61K35/57A61K38/38A61K38/085C12N5/0656A61Q19/00C12N2501/32A61L27/3804C12N2501/90A61K38/1841A61P17/00A61K2300/00
Inventor 彼得·K·罗
Owner 彼得 K 罗