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Purine derivative and its prepn process

A technology of derivatives and purines, applied in the field of purine derivatives and their preparation, to achieve the effects of increasing immunity and treating diseases in a wide range

Inactive Publication Date: 2005-12-14
宁其志 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Purine drugs in the prior art are a single type of drug and have certain side effects

Method used

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  • Purine derivative and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The preparation method of 9-calcium phosphate-adenine medicine, carries out according to the following steps:

[0062] ①. Preparation of phosphoric acid working solution: Na 2 HPO 4 9g with 85% H 3 PO 4 2.5ml, add water to 200ml and mix to make a mixed solution, and control the pH value at 6.0;

[0063] ②. Dissolve 1.5g of adenine in 450ml of water, add 200ml of the above-mentioned phosphoric acid working solution to dissolve, pour the solution into the reaction tank, place the reaction tank in a water bath at a temperature of 35°C to 39°C, and add the international code EC2. 7.3.2 creatine kinase 20mg / 50ml water, then stir for 70 minutes, keep warm at a temperature of 35°C to 39°C for 33 minutes, then let the reaction tank stand at room temperature for 30-40 minutes;

[0064] ③. Take out the above solution, filter it with a filter to obtain the filtrate; pour all the filtrate into the reaction tank, and add 10% NH 4 h 2 PO 4 After 8ml, place the reaction tank ...

Embodiment 2

[0069] The preparation method of 9-calcium phosphate-adenine medicine, carries out according to the following steps:

[0070] ①. Preparation of phosphoric acid working solution: Na 2 HPO 4 11g with 85% H 3 PO 4 3.5ml, add water to 200ml and mix to make a mixed solution, and control the pH value at 6.0;

[0071] ②. Dissolve 2.5g of adenine in 450ml of water, add 200ml of the above phosphoric acid working solution to dissolve, pour the solution into the reaction tank, place the reaction tank in a water bath at a temperature of 35°C to 39°C, and add the international code EC2. 7.3.2 creatine kinase 20mg / 50ml water, then stir for 60-70 minutes, keep warm at a temperature of 35°C to 39°C for 27-33 minutes, then let the reaction tank stand at room temperature for 30-40 minutes;

[0072] ③. Take out the above solution, filter it with a filter to obtain the filtrate; pour all the filtrate into the reaction tank, and add 10% NH 4 h 2 PO 4 After 12ml, place the reaction tank i...

Embodiment 3

[0077] The preparation method of 6,9-calcium diphosphate-adenine medicine is carried out according to the following steps:

[0078] ①. Preparation of phosphoric acid working solution: Na 2 HPO 4 9g with 85% H 3 PO 4 2.5ml, add water to 200ml and mix to make a mixed solution, and control the pH value at 6.0;

[0079] ②. Dissolve 1.5g of adenine in 450ml of water, add 200ml of the above-mentioned phosphoric acid working solution to dissolve, pour the solution into the reaction tank, place the reaction tank in a water bath at a temperature of 35°C to 39°C, and add the international code EC2. 7.3.2 creatine kinase 20mg / 50ml water, then stir for 70 minutes, keep warm at a temperature of 35°C to 39°C for 33 minutes, then let the reaction tank stand at room temperature for 35 minutes;

[0080] ③, take out above-mentioned solution, filter with filter, obtain filtrate;

[0081] ④. Pour all the filtrate into the reaction tank and add CaCl with a concentration of 10%. 2 18ml of a...

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Abstract

The present invention is purine derivatives and their preparation process. The purine derivatives have their cyclic N and exocyclic H or O substituted with phosphate radical; and includes 9-calcium phosphate-adenine medicine, 6, 9-calcium diphosphate-adenine medicine, 9-calcium phosphate-guanine medicine and 9-calcium phosphate-hypoxanthine medicine. All the medicines are white crystal or crystalline powder and smell-less, and are prepared with the material including adenine, guanine, hypoxanthine, phosphoric acid, ammonium phosphate, etc. The medicines have the function of self-selecting target to regulate immunity and treat various diseases. They have high-energy phosphoric bond with self-catalyzing and self-assembling effect to act on pathogenic site and to reach the wide-spectrum and safe treating effects, including inhibiting tumor, treating viral infection, regulating function of nerve, etc.

Description

Technical field: [0001] The present invention relates to purine derivatives and a preparation method thereof. Background technique: [0002] Purine drugs in the prior art are single-type drugs and have certain side effects. Invention content: [0003] The object of the present invention is to provide a purine derivative, which has the effect of self-selecting targets according to different pathogenic sites in the human body, and achieves the effect of one drug with multiple functions, treating both symptoms and root causes, regulating immunity and inhibiting tumors. [0004] Another object of the present invention is to provide a preparation method of purine derivatives. [0005] Another object of the present invention is to provide the use of purine derivatives in the preparation of drugs for inhibiting tumors, treating viral infections, fever, pain, regulating immunity, improving kidney function, and treating AIDS. [0006] Technical Features: [0007] See Figure 1, p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/6561
Inventor 宁其志李志辉
Owner 宁其志
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